A Probabilistic Approach for Predicting Methane Occurrence in Groundwater.

Aqueous geochemistry datasets from regional groundwater monitoring programs can be a major asset for environmental baseline assessment (EBA) in regions with development of natural gases from unconventional hydrocarbon resources. However, they usually do not include crucial parameters for EBA in areas of shale gas development such as methane concentrations. A logistic regression (LR) model was developed to predict the probability of methane occurrence in aquifers in Alberta (Canada).

New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome.

The human protein kinome comprises 535 proteins that, with the exception of approximately 50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation of multiple protein substrates. While a major research focus of the last 30 years has been cancer-associated Tyr and Ser/Thr kinases, over 85% of the kinome has been identified to be dysregulated in at least one disease or developmental disorder. Despite this remarkable statistic, for the majority of protein kinases and pseudokinases, there are currently no inhibitors progressing toward the clinic, and in most cases, details of their physiologic and pathologic mechanisms remain at least partially obscure.