Publications by authors named "Leah Ishmael"
Molecular Pathways and Potential Therapeutic Targets of Refractory Asthma.
Biology (Basel)
August 2024
Asthma is a chronic inflammatory lung disease. Refractory asthma poses a significant challenge in management due to its resistance to standard therapies. Key molecular pathways of refractory asthma include T2 inflammation mediated by Th2 and ILC2 cells, eosinophils, and cytokines including IL-4, IL-5, and IL-13.
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- Black adults experience higher rates of asthma but are often studied as a uniform group, ignoring cultural differences among subgroups.
- The study aimed to assess asthma-related health outcomes across various Black ethnic subgroups by comparing multiethnic Black (ME/B) and African American (AA/B) participants.
- Results showed that ME/B participants had more emergency room visits and higher use of systemic corticosteroids for asthma than AA/B participants, particularly among Puerto Rican Black Latinx individuals.
Elevated cardiac enzymes are often seen in the setting of sepsis. The mechanism involves hypoperfusion and possible compromise to myocardial tissue. Electrocardiogram (ECG) changes in the setting of septic shock are less common and can vary widely.
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