Publications by authors named "Leah I Prins"
Article Synopsis
- Early-onset fetal growth restriction affects roughly 0.3% of pregnancies and is linked to increased risks such as early-onset pre-eclampsia, with the aim of improving predictions for perinatal mortality.
- This analysis examined data from 215 pregnant women with severe early-onset fetal growth restriction, utilizing logistic regression to identify predictors of perinatal mortality.
- Key predictors of perinatal mortality included fetal abdominal circumference, gestational age at diagnosis, estimated fetal weight, and umbilical artery measurements; the treatment randomization did not influence mortality risk.
Introduction: In early-onset fetal growth restriction the fetus fails to thrive in utero due to unmet fetal metabolic demands. This condition is linked to perinatal mortality and severe neonatal morbidity. Maternal administration of corticosteroids in high-risk pregnancies for preterm birth at a gestational age between 24 and 34 weeks has been shown to reduce perinatal mortality and morbidity.
View Article and Find Full Text PDFMinimally-invasive tools to assess tumour presence and burden may improve clinical management. FDG-PET (metabolic) imaging is the current gold standard for interim response assessment in patients with classical Hodgkin Lymphoma (cHL), but this technique cannot be repeated frequently. Here we show that microRNAs (miRNA) associated with tumour-secreted extracellular vesicles (EVs) in the circulation of cHL patients may improve response assessment.
View Article and Find Full Text PDFBackground & Aims: Identification of factors associated with achalasia treatment outcome might help physicians select therapies based on patient characteristics. We performed a systematic review and meta-analysis to identify factors associated with treatment response.
Methods: We searched MEDLINE, EMBASE, and the Cochrane Library through February 21, 2019, for randomized controlled trials and cohort, case-control, and cross-sectional studies that reported patient-specific outcomes of treatment (botulinum toxin injection, pneumatic dilation, peroral endoscopic myotomy, or laparoscopic Heller myotomy).
Background And Aims: One of the most used treatments for achalasia is pneumatic dilation of the lower esophageal sphincter to improve esophageal emptying. Multiple treatment protocols have been described with a varying balloon size, number of dilations, inflation pressure, and duration. We aimed to identify the most efficient and safe treatment protocol.
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