Publications by authors named "Leah Haut"
Spatiotemporal orchestration of gene expression is required for proper embryonic development. The use of single-cell technologies has begun to provide improved resolution of early regulatory dynamics, including detailed molecular definitions of most cell states during mouse embryogenesis. Here we used Slide-seq to build spatial transcriptomic maps of complete embryonic day (E) 8.
View Article and Find Full Text PDFPost-implantation mammalian embryogenesis involves profound molecular, cellular, and morphogenetic changes. The study of these highly dynamic processes is complicated by the limited accessibility of development. In recent years, several complementary systems comprising self-organized assemblies of mouse embryonic stem cells, such as gastruloids, have been reported.
View Article and Find Full Text PDFArticle Synopsis
- Post-implantation embryogenesis involves complex developmental processes that are difficult to study in living organisms.
- Researchers discovered that mouse embryonic stem cells (mESCs) form aggregates that, when placed in a specific extracellular matrix, develop into structured "trunk-like structures" (TLSs) resembling parts of early mouse embryos.
- These TLSs demonstrate advanced self-organization and provide a valuable tool for exploring the mechanisms of post-implantation embryogenesis outside of the living mouse.