Publications by authors named "Leah Burkovsky"
Article Synopsis
- Dysregulated cholesterol metabolism plays a significant role in atherosclerosis, and the study examines how the AMPK-HMGCR signaling pathway affects cholesterol levels and atherosclerosis development.
- The research used two types of mice: HMGCR S871A knock-in (KI) mice and wild-type (WT) mice, both fed a high-fat and high-cholesterol diet to induce atherosclerosis, but found no significant differences in atherosclerotic plaque formation between the two.
- The findings suggest limited impact of AMPK-mediated control on cholesterol synthesis related to atherosclerosis progression, highlighting the need for further investigation into various atherosclerosis models.
A rare case of cytomegalovirus causing respiratory failure and a large pericardial effusion.
J Community Hosp Intern Med Perspect
September 2021
Article Synopsis
- CMV infection usually doesn't make healthy people sick, but it can be serious for those with weak immune systems.
- In a rare case, a patient with HIV experienced severe breathing problems and fluid around the heart because of CMV.
- Doctors found that CMV was the only germ causing these problems after examining samples from the patient's lungs and heart.
Adenosine monophosphate-activated protein kinase (AMPK) regulates multiple signaling pathways involved in glucose and lipid metabolism in response to changes in hormonal and nutrient status. Cell culture studies have shown that AMPK phosphorylation and inhibition of the rate-limiting enzyme in the mevalonate pathway 3-hydroxy-3-methylglutaryl (HMG) coenzyme A (CoA) reductase (HMGCR) at serine-871 (Ser871; human HMGCR Ser872) suppresses cholesterol synthesis. In order to evaluate the role of AMPK-HMGCR signaling we generated mice with a Ser871-alanine (Ala) knock-in mutation (HMGCR KI).
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