Publications by authors named "Leah Baxter"
Article Synopsis
- Autoimmune autonomic ganglionopathy (AAG) is a rare disease where the body mistakenly attacks a type of receptor called gAChR.
- Doctors in the U.S. usually diagnose AAG by checking for symptoms and testing for specific autoantibodies with a method called a radioimmunoprecipitation assay (RIA).
- This study suggests a new testing method called fluorescence-detection size-exclusion-chromatography (FSEC) that can also find these autoantibodies, showing it might be a good option for diagnosing AAG.
The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a homopentamer, is exceptionally permeable to Ca, and desensitizes faster than any other Cys-loop receptor. The α7 receptor has served as a prototype for the Cys-loop superfamily yet has proven refractory to structural analysis.
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