Publications by authors named "Lea Strohm"
Background: Epidemiology links noise to increased risk of metabolic diseases like diabetes and obesity. Translational studies in humans and experimental animals showed that noise causes reactive oxygen species (ROS)-mediated cardiovascular damage. The interaction between noise and diabetes, specifically potential additive adverse effects, remains to be determined.
View Article and Find Full Text PDFBackground: Emerging diagnostic modalities suggest that miRNA profiles within extracellular vesicles (EVs) isolated from peripheral blood specimens may provide a non-invasive diagnostic alternative for dementia and neurodegenerative disorders. Given that EVs confer a protective environment against miRNA enzymatic degradation, the miRNAs enriched in the EV fraction of blood samples could serve as more stable and clinically relevant biomarkers compared to those obtained from serum.
Objective: To compare miRNAs isolated from EVs versus serum in blood taken from Alzheimer's disease (AD) dementia patients and control cohorts.
Article Synopsis
- CD40L-CD40-TRAF signaling is implicated in the progression of atherosclerosis and the pathogenesis of coronary heart disease (CHD), especially in individuals with comorbid conditions like hyperlipidemia, diabetes, and hypertension.
- In mouse models with diabetes and hypertension, treatment with a TRAF6 inhibitor showed promising results by normalizing oxidative stress and inflammation markers, suggesting that this signaling pathway could serve as a therapeutic target.
- Analysis of plasma and vascular materials from CHD patients revealed a correlation between elevated inflammatory markers and comorbidities, indicating that addressing these inflammatory pathways could help reduce cardiovascular events in affected individuals.
Aims: We examined the cardiovascular effects of celiac disease (CeD) in a humanized mouse model, with a focus on vascular inflammation, endothelial dysfunction, and oxidative stress.
Methods And Results: NOD.DQ8 mice genetically predisposed to CeD were subjected to a diet regime and oral gavage to induce the disease (gluten group vs.
Article Synopsis
- Environmental stressors like traffic noise contribute to a significant loss of healthy life years and require effective prevention strategies to address health impacts, especially related to vascular dysfunction.
- In a study using mice exposed to aircraft noise, various methods of activating α1AMPK—through pharmacological means, exercise, and intermittent fasting—were found to prevent endothelial dysfunction and oxidative stress caused by the noise exposure.
- The findings suggest that activating α1AMPK specifically in endothelial cells can protect against noise-induced vascular damage, highlighting the need for further research to evaluate these interventions in human populations.
Worldwide, up to 8.8 million excess deaths/year have been attributed to air pollution, mainly due to the exposure to fine particulate matter (PM). Traffic-related noise is an additional contributor to global mortality and morbidity.
View Article and Find Full Text PDFArticle Synopsis
- - Cardiovascular diseases (CVD) are the top cause of death globally, with hypertension and related conditions accounting for about 40% of deaths, primarily due to atherosclerosis, an inflammatory issue in blood vessels.
- - Inflammation is not only a risk factor for CVD but can also aid recovery by clearing out tissue damage through a process called resolution, which is crucial after ischemic events.
- - The review explores how macrophages can have harmful (M1) or helpful (M2) effects in CVD and evaluates the complex role of the CD40L-CD40-TRAF signaling pathways, suggesting that therapies targeting these might need careful adjustments to be effective without causing adverse effects.
Objective: Neuroendoscopic procedures inside the ventricular system always bear the risk for an unexpected intraoperative hemorrhage with potentially devastating consequences. The authors present here their experience, and a stage-to-stage guide for the endoscopic management of intraoperative hemorrhages.
Methods: A step-by-step guide for the management to gain control of and stop the bleeding is described including a grading system.
Transportation noise is recognized as an important cardiovascular risk factor. Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. Here, we test for adaptation or tolerance mechanisms in mice in response to chronic noise exposure.
View Article and Find Full Text PDFObjective: The objective was to identify barriers and facilitators to the implementation of artificial intelligence (AI) applications in clinical radiology in The Netherlands.
Materials And Methods: Using an embedded multiple case study, an exploratory, qualitative research design was followed. Data collection consisted of 24 semi-structured interviews from seven Dutch hospitals.