Spatio-temporal characterization of causal electrophysiological activity stimulated by single pulse focused ultrasound: anstudy on hippocampal brain slices.

The brain operates via generation, transmission and integration of neuronal signals and most neurological disorders are related to perturbation of these processes. Neurostimulation by focused ultrasound (FUS) is a promising technology with potential to rival other clinically used techniques for the investigation of brain function and treatment of numerous neurological diseases. The purpose of this study was to characterize spatial and temporal aspects of causal electrophysiological signals directly stimulated by short, single pulses of FUS onmouse hippocampal brain slices.