Publications by authors named "Lea Perrin"
A few α-glucan debranching enzymes (DBEs) of the large glycoside hydrolase family 13 (GH13), also known as the α-amylase family, have been shown to catalyze transglycosylation as well as hydrolysis. However, little is known about their acceptor and donor preferences. Here, a DBE from barley, limit dextrinase (LD), is used as a case study.
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- Patients with severe COVID-19 in ICUs have a high risk of blood clots, prompting a study to compare the effects of intermediate-dose versus standard-dose anticoagulation.
- The study included 1,174 patients and found no significant difference in 90-day mortality or ICU stay length between the two dosing groups, but intermediate-dose patients had fewer venous thrombo-embolism (VTE) incidents.
- Both groups experienced similar rates of bleeding complications, indicating that while the doses impacted blood clot rates, they did not affect overall survival or safety.