Functional analysis of promoter variant and its possible implication in colorectal cancer immunotherapy.

Background: Colorectal cancer (CRC) is a prevalent cancer, ranking as the third most common. Recent advances in our understanding of the molecular causes of this disease have highlighted the crucial role of tumor immune evasion in its initiation and progression. , a receptor that acts as a negative regulator of T cell responses, plays a pivotal role in this process, and genetic variations in have been linked to CRC susceptibility, prognosis, and response to therapy.