Publications by authors named "Lea Neppl"
Pancreatology
December 2023
Article Synopsis
- Genetic predisposition is significant for early-onset chronic pancreatitis (CP), with some cases linked to genetic changes in digestive enzyme genes, while others remain unexplained.
- Researchers investigated CTRL, a chymotrypsin-like protease, by screening over 1,000 CP patients and 1,500 controls for genetic variants, analyzing their effects on enzyme secretion and activity.
- Although several CTRL variants were identified, many did not impact function or were equally present in both patients and controls, suggesting that CTRL is probably not a major contributor to the development of CP.
