Publications by authors named "Lea Juarez-Allen"
The aim of this study was to investigate interchangeability of two tests to diagnose Cushing's syndrome. We compared 10:00-11:00 PM urinary free cortisol/creatinine ratio (UFC/Cr) with late night 11:00 PM salivary cortisol (LNSC) in normal and obese controls vs. patients with Cushing's syndrome.
View Article and Find Full Text PDFWe evaluated results of temozolomide (TMZ) therapy in six patients, aged 34-78 years, presenting aggressive pituitary tumors. In all the patients tested O(6)-methylguanine-DNA methyltransferase (MGMT) immunoexpression in surgical specimens was absent. Patients received temozolomide 140-320 mg/day for 5 days monthly for at least 3 months.
View Article and Find Full Text PDFCollection and analysis of data obtained during the clinical treatment of pituitary tumours are of great utility in the decision making process, when facing clinical situations. We report here data on 519 from 670 patients with pituitary adenomas obtained from a computerized registry. Three hundred and forty five were females (66%) and 174 males (34%), aged 14-80.
View Article and Find Full Text PDFArticle Synopsis
- Endogenous Cushing's syndrome, although rare, is increasingly recognized, leading to more referrals to specialized medical centers due to a better understanding of its clinical features across various medical specialties.
- Symptoms are caused by excessive cortisol and can include central obesity, mood swings, fatigue, and increased risk of infections, particularly in patients with conditions like hypertension, diabetes, and metabolic syndrome.
- Effective diagnosis requires differentiation from pseudo-Cushing's conditions, with a focus on specific physical signs, and emphasizes the need for improved education and training for healthcare providers to better identify and manage this complex endocrine disorder.