Publications by authors named "Lea Habib"
Skin health relies heavily on a well-maintained cutaneous barrier. While the detrimental effects of UV radiation on the epidermis are established, the impact of blue light, a significant component of sunlight and artificial sources, is less clear. This study aims to explore blue light's influence on the reconstructed human epidermis (RHE) using two complementary analytical approaches: Raman microspectroscopy and normal phase liquid chromatography coupled with high-resolution mass spectrometry (NPLC/HR-MS).
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- Reconstructed epidermis models, derived from 3D keratinocyte cultures, are important for testing skin safety and efficacy, highlighting the need for thorough evaluation of their barrier function.
- This study uses speckle analysis and Raman microspectroscopy on Reconstructed Human Epidermis (RHE) samples at different maturation stages to assess the skin barrier.
- Results showed significant improvements in key parameters between maturation days D17 and D20, confirming that the speckle technique is an effective method for evaluating skin barrier properties in these models.