The autoimmune rheumatological presentation of Common Variable Immunodeficiency Disorders with an overview of genetic testing.

Primary immunodeficiency Disorders (PIDS) are rare, mostly monogenetic conditions which can present to a number of specialties. Although infections predominate in most PIDs, some individuals can manifest autoimmune or inflammatory sequelae as their initial clinical presentation. Identifying patients with PIDs can be challenging, as some can present later in life.

Challenges for gene editing in common variable immunodeficiency disorders: Current and future prospects.

The original CRISPR Cas9 gene editing system and subsequent innovations offers unprecedented opportunities to correct severe genetic defects including those causing Primary Immunodeficiencies (PIDs). Common Variable Immunodeficiency Disorders (CVID) are the most frequent symptomatic PID in adults and children. Unlike many other PIDs, patients meeting CVID criteria do not have a definable genetic defect and cannot be considered to have an inborn error of immunity (IEI).

Contrasting intra-individual variation in size-based trophic and habitat shifts for two coastal Arctic fish species.

Within and among species variation in trophic and habitat shifts with body size can indicate the potential adaptive capacity of species to ecosystem change. In Arctic coastal ecosystems, which experience dramatic seasonal shifts and are undergoing rapid change, quantifying the trophic flexibility of coastal fishes with different migratory tactics has received limited attention. We examined the relationships among body length and condition (Fulton's K, phase angle from Bioelectrical Impedance Analysis) with trophic and habitat shifts (differences in δN and δC between blood tissues with different turnover rates) of two abundant and culturally important species, anadromous Arctic char (Salvelinus alpinus, n = 38) and sedentary Greenland cod (Gadus ogac, n = 65) during summer in coastal marine waters near Ulukhaktok, Northwest Territories, Canada.

Selective IgA Deficiency May Be an Underrecognized Risk Factor for Severe COVID-19.

SARS-CoV-2, the agent responsible for COVID-19, has wreaked havoc around the globe. Hundreds of millions of individuals have been infected and well over six million have died from COVID-19. Many COVID-19 survivors have ongoing physical and psychiatric morbidity, which will remain for the rest of their lives.

Evidence for three morphotypes among anadromous Arctic char (Salvelinus alpinus) sampled in the marine environment.

Variable resource use and responses to environmental conditions can lead to phenotypic diversity and distinct morphotypes within salmonids, including Arctic char (Salvelinus alpinus). Despite the cultural and economic importance of Arctic char in the Inuvialuit Settlement Region (ISR), limited data exist on the extent and presence of morphological diversity in this region. This is of concern for management given climate change impacts on regional fish populations.

Exploring perceptions of eating with dementia: Findings from a massive open online course.

People with dementia are at high risk of malnutrition as a result of progressive symptoms that affect eating. Maximising opportunities to enhance nutrition and strategies to encourage eating are a crucial part of providing care. Caregiver knowledge and a person-centred approach to eating is essential to reduce symptom burden and maintain quality of life.

The (apparent) antibody paradox in COVID-19.

Introduction: The immunological response to COVID-19 is only partly understood. It is increasingly clear that the virus triggers an inappropriate host inflammatory reaction in patients experiencing severe disease.

Areas Covered: The role of antibodies in COVID-19 remains to be fully defined.

Treating Hepatitis C Virus Reinfection With 8 Weeks of Ledipasvir/Sofosbuvir Achieves Sustained Virologic Response.

Three patients reinfected with hepatitis C virus after a sustained virologic response were considered treatment naïve and treated with a short-course direct acting antiviral regimen.

An intimate connection: Exploring the visual art experiences of persons with dementia.

The purpose of this study is to describe and discuss the art experience of persons with dementia taking part in guided museum tours at a Norwegian art museum. The analysis is based on semi-structured open-ended interviews with participants and researcher field notes. The results demonstrate the capacity and willingness of persons with dementia to reach out and connect on a personal level with the artworks.

The impact of HIV on sexual functioning: Considerations for clinicians.

Cultivating a healthy sex life after HIV diagnosis can be difficult for people with HIV (PWH), as stigma and concerns for transmission may act as barriers to sexual activity. Addressing these obstacles is a necessary part of psychotherapy when helping PWH reincorporate sexual activities. However, mental health providers may be unprepared to discuss factors that impact sexual functioning with their HIV-positive clients.

Best intentions or best practice? A case study of the nutritional needs and outcomes of a person with dementia living in a residential aged care home.

Aims: To evaluate the nutritional status and needs of a person with dementia living in an aged care home, including identification of barriers to, and effective strategies for, the provision of person-centred care.

Background: Nutrition and hydration care are integral to quality of life for adults with dementia, but there is little research on whether staff knowledge around effective care strategies for residents is translated into optimal care.

Design: Focused ethnographic single-case design.

Staff awareness of food and fluid care needs for older people with dementia in residential care: A qualitative study.

Aims And Objectives: To examine awareness of aged care home staff regarding daily food and fluid care needs of older people with dementia.

Background: Older people in residential care frequently are malnourished, and many have dementia. Staff knowledge of the food and fluid needs of people with dementia is limited.

Nursing students' preferences for clinical placements in the residential aged care setting.

Aims And Objectives: To examine nursing student placement preferences submitted as online comments to a university's placement management system, to inform strategies for positive residential aged care experiences.

Background: There are predicted shortages of nurses to service an ageing population. Clinical placements undertaken by undergraduate nursing students help shape their attitudes and are a key determinant of career decision-making, yet there is little research about why students prefer particular placement areas.

"Bringing the outside world in": Enriching social connection through health student placements in a teaching aged care facility.

Background: Older adults living in residential aged care facilities (RACFs) often experience limited opportunities for social connection despite close proximity to peers, which has implications for mental health and quality of life (QoL). The introduction of large-scale undergraduate health student placements in RACFs may enhance opportunities for meaningful engagement through social connection, although this remains unexplored.

Objective: This research explores whether interpersonal encounters between health students and RACF residents influence residents' opportunities for social connection and QoL.

Transitioning Former Military Medics to Civilian Health Care Jobs: A Novel Pilot Program to Integrate Medics Into Ambulatory Care Teams for High-Risk Patients.

Despite their medical training, record of military service, and the unmet needs within the health care sector, numerous challenges face veterans who seek to leverage their health care skills for employment after leaving the military. Creative solutions are necessary to successfully leverage these skills into jobs for returning medics that also meet the needs of health care systems. To achieve this goal, we created a novel ambulatory care health technician position on the basis of existing literature and modeled after a program which incorporates former military medics in emergency departments.

Using action research to build mentor capacity to improve orientation and quality of nursing students' aged care placements: what to do when the phone rings.

Aims And Objectives: To describe whether an action research approach can be used to build capacity of residential aged care facility staff to support undergraduate nursing students' clinical placements in residential aged care facilities, using development of an orientation programme as an exemplar.

Background: Aged care facilities are unpopular sites for nursing students' clinical placements. A contributing factor is the limited capacity of staff to provide students with a positive placement experience.

Encountering aged care: a mixed methods investigation of medical students' clinical placement experiences.

Background: Residential aged care is an increasingly important health setting due to population ageing and the increase in age-related conditions, such as dementia. However, medical education has limited engagement with this fast-growing sector and undergraduate training remains primarily focussed on acute presentations in hospital settings. Additionally, concerns have been raised about the adequacy of dementia-related content in undergraduate medical curricula, while research has found mixed attitudes among students towards the care of older people.

Developing networks between residential aged care facilities as a result of engagement in a falls prevention project: an action research study.

Background: Residential aged care facility (RACF) staff often operate in isolation. Research is lacking on networking between facilities.

Aims: To explore outcomes associated with network formation between two RACFs as part of an action research approach to reducing falls.

Rainbow trout in seasonal environments: phenotypic trade-offs across a gradient in winter duration.

Survival through periods of resource scarcity depends on the balance between metabolic demands and energy storage. The opposing effects of predation and starvation mortality are predicted to result in trade-offs between traits that optimize fitness during periods of resource plenty (e.g.

Aspects of nursing student placements associated with perceived likelihood of working in residential aged care.

Aims And Objectives: To investigate which aspects of student nurses' experiences of residential aged care facility clinical placements affect perceived likelihood of choosing a career in residential aged care post graduation.

Background: Poor clinical placement experiences as a student contribute to nurses' reluctance to work in aged care. Various factors have been found to improve the placement experience and influence students' attitudes and employment intentions.

Wicking teaching aged care facilities program: Innovative Practice.

This paper reports on the design of a program that aims to prototype teaching aged care facilities in Australia. Beginning in two Tasmanian residential aged care facilities, the intent of the program is to support large-scale inter-professional student clinical placements, positively influence students' attitudes toward working in aged care and drive development of a high-performance culture capable of supporting evidence-based aged care practice. This is important in the context of aged care being perceived as an unattractive career choice for health professionals, reinforced by negative clinical placement experiences.

An investigation of nursing students' knowledge of dementia: A questionnaire study.

Background: Globally, rising rates of dementia indicate the need for more nurses skilled in caring for people with this condition. However nursing students may not acquire the requisite knowledge from existing undergraduate curricula.

Objectives: To investigate the dementia knowledge of second-year nursing students before and after a supported placement in a residential aged care facility.

Are care workers appropriate mentors for nursing students in residential aged care?

Background: The aged care sector is increasingly dominated by a less-qualified workforce at a time of increasing prevalence of complex health concerns, such as dementia. An Australian program to develop teaching aged care facilities is being undertaken to build the sector's capacity and provide nursing students with positive experiences of engaging with vulnerable clients. This research aimed to examine care staff potential to facilitate nursing student engagement with clinically relevant knowledge in the performance of hygiene care in a residential aged care facility.

Improving student nurses' aged care understandings through a supported placement.

Aim: The study aimed to identify the potential for aged care placements to deliver benefits for second year nursing students when conducted within a supportive framework with debriefing and critical reflection opportunities.

Background: Given the ageing population and complex care needs of aged care facility residents, exacerbated by the high prevalence of dementia, the healthcare workforce's ability to meet older people's care needs is paramount. Yet research shows that nursing students are disengaged from aged care.