Publications by authors named "Lea Dehgane"
Article Synopsis
- * The study revealed that CLL cells rely heavily on fatty acid beta-oxidation for energy, and inhibiting the enzyme ACOX1 can shift their metabolism and lead to cell death, even in challenging cases.
- * Combining ACOX1 inhibition with BTK inhibitors showed enhanced effectiveness in eliminating CLL cells while leaving healthy blood cells unharmed, suggesting a promising direction for novel, metabolism-focused therapies.
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, the prognosis of which varies according to the cytogenetic group. We characterized a rare chromosomal abnormality (del(8p), deletion of the short arm of chromosome 8) in the context of CLL. By comparing the largest cohort of del(8p) CLL to date (n = 57) with a non-del(8p) cohort (n = 155), del(8p) was significantly associated with a poor prognosis, a shorter time to first treatment, worse overall survival (OS), and a higher risk of Richter transformation.
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