Publications by authors named "Lea Catharina Berkhout"
Br J Pharmacol
April 2024
Article Synopsis
- Millions of patients use TNF inhibitors for inflammatory diseases, but the effectiveness varies due to differences in how drugs are cleared from the body, which may be influenced by TNF-TNFi complexes.
- Researchers focused on understanding how different types of TNF inhibitors, particularly their structural characteristics, affect the clearance and levels of TNF in patients with conditions like arthritis and ulcerative colitis.
- Findings indicate that TNF levels are significantly higher with certolizumab compared to other inhibitors, and the ability of macrophages to internalize these complexes is linked to the antibody structure, impacting TNF's clearance rate but not its production.
