Boron containing magnetic nanoparticles for neutron capture therapy--an innovative approach for specifically targeting tumors.

The selective delivery of (10)B into the tumor tissue remains to be further improved for successful and reliable Boron Neutron Capture Therapy applications. Magnetic Drug Targeting using intraarterially administered superparamagnetic nanoparticles and external magnetic fields already exhibited convincing results in terms of highly efficient and selective drug deposition. Using the same technique for the targeted (10)B delivery is a promising new approach.

Position sensitive measurement of lithium traces in brain tissue with neutrons.

Purpose: The application of lithium is well known to have an antimanic-depressive effect, however, the influence it has on the human brain is still insufficiently known. The aim of our work is to develop a method to investigate the lithium concentration in the human brain with a very high sensitivity and a submillimeter resolution. Present methods either do not provide spatial resolution or are not sensitive enough to measure the naturally occurring lithium content in the human brain.

PGAA, PGAI and NT with cold neutrons: test measurement on a meteorite sample.

First comprehensive analysis with PGAA, Prompt Gamma-ray Activation Imaging (PGAI) and neutron tomography (NT) techniques at the research reactor FRM II was tested on a piece of the Allende meteorite. With the PGAA method the bulk elemental composition of the heterogeneous meteorite was determined. Due to the small dimension of the sample, only the 2D elemental distribution of the object was derived with position sensitive PGAI analysis.