DExD-Box Helicase 21 Enhances Myometrial Contractions Through Thrombospondin-1-Mediated Increase in Cell Adhesion.

During labour, the myometrium transitions from a quiescent to an actively contracting state, governed by changes in gene expression. Identifying the pivotal transcription regulators involved in these gene expression alterations offers a useful strategy for addressing abnormal myometrial contractions. This study determined that the transcriptional regulator DExD-Box Helicase 21 (DDX21) is upregulated in human myometrial tissues and myometrial smooth muscle cells (hMSMCs) during labour.

The physical and psychological effects of dance therapy on middle-aged and older adult with arterial hypertension: A systematic review.

Objective: To systematically review the intervention effect of dance therapy on the physical and psychological health level of middle-aged and older adult with arterial hypertension.

Methods: The databases including the Cochrane Library, PubMed, Web of Science, EBSCO, CNKI, VIP, WANFANG DATA, and Bailianyun Library, which were searched for the randomized controlled trials for identifying the effect of dance intervention on the blood pressure. The literature published from the establishment of the database to May 10, 2023, was collected for analysis.

Unlocking new electron transport routes: Insights into enhanced long-chain fatty acid conversion in valorization of lipid-rich waste.

In this study, the alkaline fermentation of combined lipid-rich waste (LRW) was explored to produce volatile fatty acids (VFAs). By introducing sulfate as an external electron acceptor, the long-chain fatty acid (LCFA) metabolic pathway was enhanced, achieving a VFA yield of 671.1 ± 21.

Stanniocalcin-1 in tumor immunity: acts via macrophages.

Tumor immune escape has become a research hotspot in the field of cancer immunotherapy. Tumor-associated macrophages (TAMs) are the key component of tumor microenvironment, which play a pivotal role in tumor immune escape by regulating the immunity checkpoints, inhibiting the activity of T lymphocytes and natural killer (NK) cells, and modulating proportion of different T cells. Stanniocalcin-1(STC1)is ubiquitously expressed in human body, which is proven to involve with tumor progression and clinical prognosis.

MDV-encoded protein kinase U3 phosphorylates WTAP to inhibit transcriptomic mA modification and cellular protein translation.

Marek's disease virus (MDV)-encoded U3 is a highly conserved serine/threonine protein kinase in alpha-herpesviruses. In other alpha-herpesviruses, such as pseudorabies virus (PRV), U3 phosphorylates the N6-methyladenosine (mA) methyltransferase Wilms tumor 1-associated protein (WTAP), inhibiting mA modification. However, the role and mechanism of U3-mediated WTAP phosphorylation during MDV infection remain undefined.

The role of DDR1 in cancer and the progress of its selective inhibitors.

Discoidin domain receptor 1 (DDR1) is a member of the receptor tyrosine kinase superfamily, which mainly activates downstream signaling pathways through binding to collagen. The abnormal expression of DDR1 is closely related to the occurrence and development of various tumors, and it is one of the potential targets for molecular targeted therapy. At present, specific antibodies and selective small molecule inhibitors against DDR1 have been approved for Phase I clinical trials.

induces MST2 phosphorylation mediating the activation of hippo signaling pathway to promote apoptosis and lung tissue damage.

() is an intracellular parasite, and its regulation of host cell apoptosis directly affects its parasitism. Studies link -induced apoptosis to abnormal expression of mammalian STE20-like protein kinase 2 (MST2), but its precise role remains unclear. In this study, the regulatory roles in apoptosis and pathogenicity of infection were identified and .

Development of flexible Zn/MnO secondary batteries using a fumed silica-doped hydrogel electrolyte.

Hydrogel electrolytes have received tremendous research interest in designing flexible zinc-ion secondary batteries, making them highly promising for flexible energy storage and wearable electronic devices. Herein, we report a composite hydrogel electrolyte (CHE) prepared using a fumed silica-doped gelatin hydrogel. This electrolyte is specifically designed for use in rechargeable aqueous Zn/MnO batteries (ReAZMBs).

Optical skyrmions from metafibers with subwavelength features.

Optical skyrmions are an emerging class of structured light with sophisticated particle-like topologies with great potential for revolutionizing modern informatics. However, the current generation of optical skyrmions involves complex or bulky systems, hindering the development of practical applications. Here, exploiting the emergent "lab-on-fiber" technology, we demonstrate the design of a metafiber-integrated photonic skyrmion generator.

Wide-field imaging and recognition through cascaded complex scattering media.

Considering the obvious application value in the field of minimally invasive and non-destructive clinical healthcare, we explore the challenge of wide-field imaging and recognition through cascaded complex scattering media, a topic that has been less researched, by realizing wide-field imaging and pathological screening through multimode fibers (MMF) and turbid media. To address the challenge of extracting features from chaotic and globally correlated speckles formed by transmitting images through cascaded complex scattering media, we establish a deep learning approach based on SMixerNet. By efficiently using the parameter-free matrix transposition, SMixerNet achieves a broad receptive field with less inductive bias through concise multi-layer perceptron (MLP).

Postmortem/dynamic distribution of ethanol and its nonoxidative metabolites in poisoned rabbits.

Nonoxidative ethanol metabolites have been reported as ethanol biomarkers in clinical and forensic cases. However, their forensic toxicokinetics are still unclear. The study aimed to simultaneously research the postmortem distribution and dynamic distribution of ethanol and its nonoxidative metabolites in 62 poisoned rabbits.

Tandem Cyclization of -Hydroxyphenyl Propargyl Alcohols with Thionucleophiles: A Metal-Free and Modular Access to 3-Fluoroalkylsulfonyl/Thio Benzofurans.

Despite both fluoroalkylsulfonyl groups and benzofurans are important bioactive moieties, the construction of fluoroalkanesulfonylated benzofurans that incorporate these two fragments remains underdeveloped. Here, we report a tandem cyclization protocol to construct a wide range of 3-fluoroalkylsulfonyl benzofurans using readily accessible -hydroxyphenyl propargyl alcohols and sodium fluoroalkanesulfinates. Furthermore, this synthetic strategy can also be adapted to prepare 3-thio benzofurans by changing the S-nucleophiles to thiols or thiophenols.

Hypermethylation of CDKN2A CpG island drives resistance to PRC2 inhibitors in SWI/SNF loss-of-function tumors.

Polycomb repressive complex 2 (PRC2) catalyzes the writing of the tri-methylated histone H3 at Lys27 (H3K27me3) epigenetic marker and suppresses the expression of genes, including tumor suppressors. The function of the complex can be partially antagonized by the SWI/SNF chromatin-remodeling complex. Previous studies have suggested that PRC2 is important for the proliferation of tumors with SWI/SNF loss-of-function mutations.

Ambient air pollution exposure, plasma metabolomic markers, and risk of type 2 diabetes: A prospective cohort study.

Background: Both air pollution (AP) and impaired lipid metabolism contribute to type 2 diabetes (T2D). However, little is known about the detailed associations of AP to lipidomic markers and the specific lipid metabolomic profile that mediates the impact of AP on incident T2D. We aimed to examine the associations between long-term AP exposure, plasma metabolomic markers, and incident T2D, and subsequently determine the lipid metabolomic profile that mediates the relationship between AP and T2D.

Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway.

This study aims to investigate whether butylphthalide can inhibit ferroptosis and ameliorate cerebral ischaemia-reperfusion (I/R) injury in rats by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) / heme oxygenase-1 (HO-1) signalling pathway, known for its antioxidative and cytoprotective properties. Middle cerebral artery occlusion reperfusion (MCAO/R) rat models were established. Male rats were randomly divided into five groups: a sham-operated group (sham), MCAO/R group, MCAO/R ​+ ​ML385 (Nrf2-specific inhibitor) group, MCAO/R ​+ ​NBP (butylphthalide) group and MCAO/R ​+ ​ML385 ​+ ​NBP group.

Improving integrated perinatal care for women with hepatitis B in China.

argue that integrated care for women with hepatitis B in China needs improving, including better severity stratification, comprehensive counselling and education, seamless multidisciplinary care, and better referral

The Aryl Hydrocarbon Receptor Regulates Invasiveness and Motility in Acute Myeloid Leukemia Cells through Expressional Regulation of Non-Muscle Myosin Heavy Chain IIA.

Acute myeloid leukemia (AML) is the most prevalent type of hematopoietic malignancy. Despite recent therapeutic advancements, the high relapse rate associated with extramedullary involvement remains a challenging issue. Moreover, therapeutic targets that regulate the extramedullary infiltration of AML cells are still not fully elucidated.

Electron Tandem Transport Channel in a CuP/Sv-ZnInS p-n Heterojunction for Photothermal-Photocatalytic Benzyl Alcohol Oxidation and H Production.

The development of photocatalytic systems with an electron tandem transport channel represents a promising avenue for improving the utilization of photogenerated electrons and holes despite encountering significant challenges. In this study, ZnInS (Sv-ZIS) with sulfur vacancies was fabricated using a solvothermal technique to create defect energy levels. Subsequently, CuP nanoparticles were coupled onto the surface of Sv-ZIS, forming a CuP/Sv-ZIS p-n heterojunction with an electron tandem transport channel.