(Z)-Methyl 3-(2,4-dichloro-phen-yl)-3-hy-droxy-acrylate.

The mol-ecular structure of the title compound, C(10)H(8)Cl(2)O(3), exists in a cis-enol form, which is stabilized by a strong intra-molecular O-H⋯O hydrogen bond. In the crystal, C-H⋯O inter-actions generate zigzag chains along the c axis which are, in turn, linked by further C-H⋯O inter-actions into sheets parallel to (100).

Synthesis and in-vitro antibacterial activity of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivatives.

A series of novel 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivatives was designed, synthesized and characterized by (1)H-NMR, MS and HRMS. These fluoroquinolones were evaluated for their in-vitro antibacterial activity against representative Gram-positive and Gram-negative strains. Generally, all of the target compounds display rather weak potency against the tested Gram-negative strains, but most of them exhibit good potency in inhibiting the growth of S.