Publications by authors named "Le-Shi Zhang"
Article Synopsis
- Long-term potentiation (LTP) in the anterior cingulate cortex (ACC) plays a vital role in learning and chronic pain, involving AMPAR GluA1 in synaptic changes.
- After peripheral nerve injury, specific pyramidal cells in the ACC become more active and enhance synaptic transmission, contributing to chronic pain.
- Targeting the top-down modulation from the ACC to the spinal cord may offer new treatment approaches for neuropathic pain.
[Mesenchymal stem cells for treatment of steroid-resistant chronic graft-versus-host disease].
Zhonghua Nei Ke Za Zhi
July 2009
Objective: To assess whether treatment with mesenchymal stem cells (MSCs) is an effective adjunct therapy for refractory extensive chronic graft-versus-host disease (GVHD) resistant to conventional therapy.
Methods: 12 patients with steroid-resistant extensive chronic GVHD were treated with MSCs. One patient received one dose, 10 received two doses, and the remaining three doses.
[Identification of acute lymphoctic leukemia extramedullary relapse and PTLD after allo-HSCT by monitoring sex chromosome chimeric status with FISH].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
April 2009
Objective: To explore the role of monitoring sex chromosome chimeric status by fluorescence in situ hybridization (FISH) in the identification of leukemic extramedullary relapse and post-transplant lymphoproliferative disease (PTLD) in acute lymphocytic leukemia (ALL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Methods: Six ALL patients who received sex-mismatched allo-HSCT and manifested extravisceral lymphadenectasis or local lump were investigated. The sex chromosome chimeric status in tumor tissues and bone marrows (BM) were monitored by FISH, and EBV-RNA in the tumor tissues were detected by in situ hybridization (ISH).