HDAC1: An Essential and Conserved Member of the Diverse Zn-Dependent HDAC Family Driven by Divergent Selection Pressure.

Zn-dependent histone deacetylases (HDACs) are enzymes that regulate gene expression by removing acetyl groups from histone proteins. These enzymes are essential in all living systems, playing key roles in cancer treatment and as potential pesticide targets. Previous phylogenetic analyses of HDAC in certain species have been published.