Trimethylamine N-Oxide increases soluble fms-like tyrosine Kinase-1 in human placenta via NADPH oxidase dependent ROS accumulation.

Backgrounds: Preeclampsia (PE) is characterized as placental vascular disturbance and excessive secretion of soluble fms-like tyrosine kinase 1 (sFlt-1) into the maternal circulation. Trimethylamine N-oxide (TMAO, a gut microbe-derived metabolite) is strongly associated with various cardiovascular and cerebrovascular diseases. Recently, we observe that higher maternal circulating TMAO and sFlt-1 in patients with PE.

A Cd -Based Metal-Organic Framework with pcu Topology as Turn-On Fluorescent Sensor for Al.

A new metal-organic framework (MOF) {[Cd (bbib) (ndc) ]⋅2DMF} (JXUST-1) (bbib=1,3-bis(benzimidazolyl)benzene, H ndc=1,4-naphthalenedicarboxylic acid, DMF=N,N-dimethylformamide) has been solvothermally synthesized and characterized by single-crystal X-ray diffraction, PXRD, TGA, IR and elemental analysis. JXUST-1 exhibits a three-dimensional 6-connected pcu topology with a Schläfli symbol {4 .6 } constructed by [Cd (CO ) ] secondary building units.