Publications by authors named "Le-Lin Pan"
Article Synopsis
- The study explored how the gut microbiome impacts the progression of colorectal cancer (CRC) by sequencing specific regions of a gene in 66 CRC patients.
- Researchers grouped patients based on tumor characteristics and compared microbial profiles in various tissue samples.
- The results revealed significant differences in certain microbial genera between tumor and normal tissues, as well as between distal and proximal CRC segments, suggesting potential diagnostic and therapeutic implications for CRC patients.
The previous cancer studies were difficult to reproduce since the tumor tissues were analyzed directly. But the tumor tissues were actually a mixture of different cancer cells. The transcriptome of single-cell was much robust than the transcriptome of a mixed tissue.
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- - The study aims to explore how B7-H1, a protein involved in immune response, affects persistent hepatitis B virus (HBV) infection by comparing its expression in chronic HBV tolerance patients and acute hepatitis B patients.
- - Researchers used various methods to analyze B7-H1 levels in both peripheral and liver tissues, finding significant differences: AHB patients showed increased B7-H1 compared to CHB-T patients, where B7-H1-positive cells were nearly absent despite high HBsAg levels.
- - In vitro experiments demonstrated that treatment with hepatitis B surface antigen (HBsAg) downregulated CD40 and B7-H1 expression on dendritic cells, which led to impaired interactions between these cells and T cells