A drug repurposing approach for individualized cancer therapy based on transcriptome sequencing and virtual drug screening.

RNA-sequencing has been proposed as a valuable technique to develop individualized therapy concepts for cancer patients based on their tumor-specific mutational profiles. Here, we aimed to identify drugs and inhibitors in an individualized therapy-based drug repurposing approach focusing on missense mutations for 35 biopsies of cancer patients. The missense mutations belonged to 9 categories (ABC transporter, apoptosis, angiogenesis, cell cycle, DNA damage, kinase, protease, transcription factor, tumor suppressor).

Closed-Form Expression for the Symbol Error Probability in Full-Duplex Spatial Modulation Relay System and Its Application in Optimal Power Allocation.

Full-duplex (FD) communication and spatial modulation (SM) are two promising techniques to achieve high spectral efficiency. Recent works in the literature have investigated the possibility of combining the FD mode with SM in the relay system to benefit their advantages. In this paper, we analyze the performance of the FD-SM decode-and-forward (DF) relay system and derive the closed-form expression for the symbol error probability (SEP).