Publications by authors named "Le Shi"

Calcium is a vital trace element for the human body, and its deficiency can result in a range of pathological conditions, including rickets and osteoporosis. Despite the numerous types of calcium supplements currently available on the market, these products are afflicted with a number of inherent deficiencies, such as low calcium content, poor aqueous solubility, and low human absorption rate. Many microorganisms, particularly beneficial microorganisms, including edible fungi, lactic acid bacteria, and yeast, are capable of absorbing and enriching calcium, a phenomenon that has been widely documented.

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The liquefied natural gas and adsorbed natural gas (LNG-ANG) coupling systems are emerging as an attractive solution to solve boil-off gases generated by LNG tanks. Metal-organic frameworks (MOFs) are promising candidates for methane storage and delivery owing to their high porosity, large specific surface area, and tunable pore structures. However, systematically tuning LNG-ANG-related methane adsorption performance of MOFs has yet to be explored.

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Direct methanol fuel cells (DMFCs) offer a promising power source by utilizing liquid-state methanol as fuel, providing easy storage and transportability. Currently, DMFCs commonly employ perfluorosulfonic acid membranes, such as the well-known Nafion membrane, as proton exchange membranes. However, perfluorosulfonic acid membranes have significant drawbacks in DMFCs, including a high crossover rate, substantial swelling, poor thermal stability, and elevated costs.

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2D metal-organic frameworks (2D-MOFs) are an important class of functional porous materials. However, the low porosity and surface area of 2D-MOFs have greatly limited their functionalities and applications. Herein, the rational synthesis of a class of mos-MOFs with molybdenum disulfide (mos) net based on the assembly of trinuclear metal clusters and 3-connected tripodal organic ligands is reported.

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Objective: Type 2 diabetes mellitus (T2DM) is characterized by numerous long-term complications, in which progressive cognitive decline represents a significant risk factor for dementia and other neurodegenerative disorders. Taohe Chengqi decoction (THCQ) is a common traditional Chinese formula for treating T2DM; however, the neuroprotective effect of THCQ on diabetes-associated cognitive dysfunction remains unclear. Hence, the present study investigated the therapeutic effects of THCQ on cognitive impairment associated with T2DM and elucidated the underlying mechanisms.

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Non-alcoholic fatty liver disease (NAFLD) is the predominant metabolic liver disorder and currently lacks effective and safe pharmaceutical interventions. Daphnetin (DA), a natural coumarin derivative with anti-inflammatory and antioxidant activities, is a promising agent for NAFLD treatment. In this study, we evaluated the effects and mechanisms of DA on hepatic lipid metabolism in ob/ob mice.

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Background: The association between objective imaging findings and subjective symptoms remains undefined.

Aims: To investigate the correlation between objective imaging findings and symptom severity in the overall chronic rhinosinusitis with nasal polyps (CRSwNP) population as well as its subendotypes according to the eosinophilic inflammation.

Methods: Patients with CRSwNP undergoing endoscopic sinus surgery were included.

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Article Synopsis
  • - Researchers explored how negative emotional memories are processed while we sleep, focusing on whether this memory reprocessing changes throughout the night, particularly during specific sleep cycles.
  • - They found that the second sleep cycle after learning negative memories is the most critical period for this memory reprocessing, with slow oscillations and spindle activity supporting this process.
  • - An intervention using transcranial alternating current stimulation (tACS) to disrupt the identified SO-spindle coupling showed a significant decrease in the ability to recognize negative emotional memories, highlighting potential implications for treating psychiatric conditions related to emotional memory issues.
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  • Chronic rhinosinusitis with nasal polyps (CRSwNP) can be categorized into eosinophilic and noneosinophilic types based on eosinophil levels, with neutrophils being key players in the inflammation process.
  • A study analyzed neutrophils from CRSwNP polyps, revealing five functional subsets and highlighting distinct behaviors in eosinophilic (eCRSwNP) and noneosinophilic (neCRSwNP) cases, particularly with GBP5+ neutrophils showing strong activity in neCRSwNP.
  • The research demonstrated that neutrophils release oncostatin M (OSM), interacting with epithelial cells and fibroblasts, which may enhance immune responses and contribute to the development of CR
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  • Formononetin (FMN) is a natural compound from certain plants that may help fight diseases, especially liver problems.
  • This study showed that FMN protects mice from liver damage caused by specific chemicals and helps stop certain liver cells from turning bad.
  • FMN works by changing the way certain proteins act in the liver, which helps older cells survive and reduces liver scarring.
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In this study, we investigate aqueous proton penetration behavior across four types of two-dimensional (2D) nanoporous materials with similar pore sizes using extensive ReaxFF molecular dynamics simulations. The results reveal significant differences in proton penetration energy barriers among the four kinds of 2D materials, despite their comparable pore sizes. Our analysis indicates that these variations in energy barriers stem from differences in the hydrogen bond (HB) network formed between the 2D nanoporous materials and the aqueous environment.

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Metalo hydrogen-bonded organic frameworks (MHOFs) have received growing interest in designing crystalline functional materials. However, reports on bifunctional MHOFs showing magnetic and proton-conductive properties are extremely limited and their design is challenging. Herein, we investigated the magnetic and proton-conductive properties of two sulfonated and , {M(HO)(abs)} (M = Co and Mn, Habs = 4-aminoazobenzene-4'-sulfonic anion), constructed by coordination chains.

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Numerous studies have indicated a close association between gut microbiota dysbiosis, inflammation, and cognitive impairment, highlighting their crucial role in the aging process. 2-(3,4-Dihydroxyphenyl)ethyl 3-hydroxybutanoate (HTHB), a novel derivative of hydroxytyrosol, known for its metabolic and anti-inflammatory properties, was investigated for its effects on memory, inflammation, and gut microbiota in senescence-accelerated mouse prone 8 mice. The study employed behavioral testing, biochemical detection, and 16S RNA analysis.

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Habitual daytime napping is a common behavioral and lifestyle practice in particular countries and is often considered part of a normal daily routine. However, recent evidence suggests that the health effects of habitual daytime napping are controversial. We systematically searched PubMed, Web of Science, Embase, and Cochrane Library databases from inception to March 9, 2024, to synthesize cohort studies of napping and health outcome risk.

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Article Synopsis
  • The study analyzed the link between a healthy lifestyle and sleep health among the general population in China, using an online survey of over 41,000 participants.
  • Healthy lifestyle factors included a nutritious diet, regular exercise, non-smoking, no alcohol consumption, low sedentary behavior, and normal weight, dividing participants into healthy, average, and unhealthy lifestyle groups.
  • Results showed that individuals with a healthy lifestyle were significantly more likely to experience better sleep quality and duration, healthier sleep patterns, and lower risks of sleep disorders like insomnia and excessive daytime sleepiness.
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  • Sleep deprivation can cause problems in the brain like poor thinking and mood issues by messing with tiny energy factories called mitochondria and causing inflammation.
  • In tests with rats that hadn't slept, researchers found that their brains got stressed and damaged, leading to increased inflammation and more harmful substances called cytokines.
  • A new treatment using a special nutrient called hydroxytyrosol butyrate (HTHB) helped improve behavior in sleep-deprived rats and reduced the brain damage, suggesting it might help with mental health problems caused by lack of sleep.
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  • Zeolites, specifically H-MOR, H-ZSM-5, and H-Y, are studied as supports for Pd catalysts in lean methane combustion to understand their structural effects and deactivation mechanisms.
  • Pd/H-MOR demonstrated the best overall performance with the lowest activation energy, while Pd/H-ZSM-5 had the highest turnover frequency due to its larger Pd particle structure, which provided more active sites.
  • Both Pd/H-MOR and Pd/H-ZSM-5 showed stability under dry conditions, but introducing moisture significantly reduced their methane conversion rates due to dealumination and Pd aggregation, respectively.
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Study Objectives: To investigate the relationships between longitudinal changes in sleep stages and the risk of cognitive decline in older men.

Methods: This study included 978 community-dwelling older men who participated in the first (2003-2005) and second (2009-2012) sleep ancillary study visits of the Osteoporotic Fractures in Men Study. We examined the longitudinal changes in sleep stages at the initial and follow-up visits, and the association with concurrent clinically relevant cognitive decline during the 6.

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Microbial electrosynthesis (MES) cells exploit the ability of microbes to convert CO into valuable chemical products such as methane and acetate, but high rates of chemical production may need to be mediated by hydrogen and thus require a catalyst for the hydrogen evolution reaction (HER). To avoid the usage of precious metal catalysts and examine the impact of the catalyst on the rate of methane generation by microbes on the electrode, we used a carbon felt cathode coated with NiMo/C and compared performance to a bare carbon felt or a Pt/C-deposited cathode. A zero-gap configuration containing a cation exchange membrane was developed to produce a low internal resistance, limit pH changes, and enhance direct transport of H to microorganisms on the biocathode.

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  • COVID-19 survivors exhibit persistent cognitive, psychiatric, and neurological symptoms long after recovery, with the underlying neurological mechanisms still unclear.
  • In a study with 52 COVID-19 survivors and 35 healthy controls, brain functional activity was measured using resting-state fMRI to assess differences in cognitive performance and neuroimaging results.
  • The findings indicated that survivors reported higher cognitive complaints and displayed altered brain activity patterns compared to healthy individuals, highlighted by increased activity in certain brain regions and decreased activity in others, regardless of the severity of their initial COVID-19 symptoms.
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With the prosperity of the development of carbon nanorings, certain topologically or functionally unique units-embedded carbon nanorings have sprung up in the past decade. Herein, we report the facile and efficient synthesis of three cyclooctatetraene-embedded carbon nanorings (COTCNRs) that contain three (COTCNR1 and COTCNR2) and four (COTCNR3) COT units in a one-pot Yamamoto coupling. These nanorings feature hoop-shaped segments of Gyroid (G-), Diamond (D-), and Primitive (P-) type carbon schwarzites.

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Systemic lupus erythematosus (SLE) is a complex autoimmune disease of unknown etiology. It is marked by the production of pathogenic autoantibodies and the deposition of immune complexes. Lupus nephritis (LN) is a prevalent and challenging clinical complications of SLE.

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Shift work may adversely affect individuals' health, thus, the current study aimed to investigate the association between shift work and health outcomes in the general population. A total of 41,061 participants were included in this online cross-sectional survey, among which 9612 (23.4%) individuals engaged in shift work and 31,449 (76.

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Herein, we report the synthesis of a two-dimensional metal-organic framework (MOF), assembled from octahedral metal-organic cages featuring phenanthroline-based carboxylate linkers and μ-oxo-centered trinuclear Sc(III) inorganic building blocks. We study the performance of this MOF towards the capture of sulfur hexafluoride (SF). On account of its structural features and porous nature, this MOF displays an SF uptake capacity of 0.

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