Publications by authors named "Le H Doanh"
Background: This study aimed to measure the associations between different inflammatory factors, namely interleukin (IL)-17A, tumor necrosis factor (TNF)-α, and high-sensitivity C-reactive protein (hs-CRP), and atherosclerosis in patients with psoriasis vulgaris.
Methods: A cross-sectional study was conducted at two hospitals in Hanoi, Vietnam. A total of 125 patients with psoriasis vulgaris and 50 healthy controls were recruited.
Background Generalized pustular psoriasis (GPP) is a chronic disease associated with genetic factors related to mutations of the interleukin 36 receptor antagonist gene (IL36RN) and the caspase recruitment domain 14 gene (CARD14). However, the relevance of these mutations to the clinical features and severity of GPP remains unclear. Aims Our objective was to correlate the presence of IL36RN and CARD14 mutations with the clinical and laboratory findings in patients with GPP.
View Article and Find Full Text PDFBackground: Bosentan is effective agent in scleroderma vasculopathy. However, there are no studies evaluating effectiveness of bosentan in Vietnamese patients, where nifedipine is still the common treatment.
Objective: To compare the efficacy of bosentan versus nifedipine in scleroderma vasculopathy in Vietnamese patients.
Article Synopsis
- The study aimed to evaluate the effectiveness and working mechanism of an anti-CX CL1 monoclonal antibody in treating systemic sclerosis (SSc).
- Researchers used cultured human skin cells and models of SSc to assess the impact of this antibody on various skin-related factors, including inflammation and collagen buildup.
- The results indicated that anti-CX CL1 mAb significantly reduced specific signaling pathways and cellular infiltration linked to skin fibrosis, suggesting its potential as a new treatment option for early stages of fibrosis in SSc.