Helminth infection induces non-functional sensitization to house dust mites.

Background: IgE characterizes the humoral response of allergic sensitization but less is known about what modulates its function and why some patients present clinical symptoms for a given IgE level and others do not. An IgE response also occurs during helminth diseases, independently of allergic symptoms. This response could be a model of non-functional IgE.

Hookworm treatment induces a decrease of suppressive regulatory T cell associated with a Th2 inflammatory response.

Background: Like other helminths, hookworms (HW) induce a regulatory immune response able to modulate and dampen reactivity of the host to antigens. No data about the evolution of the immune response after treatment are available. We aim to phenotype the regulatory immune response during natural HW infection and its evolution after treatment.

Kinetics of CD4 T Helper and CD8 Effector T Cell Responses in Acute Dengue Patients.

The protective or pathogenic role of T lymphocytes during the acute phase of dengue virus (DENV) infection has not been fully understood despite its importance in immunity and vaccine development. This study aimed to clarify the kinetics of T lymphocyte subsets during the clinical course of acute dengue patients. In this hospital-based cohort study, 59 eligible Vietnamese dengue patients were recruited and admitted.