Evaluation of a tumor marker gastrin-releasing peptide precursor in the patients with kidney injuries.

Gastrin-releasing peptide precursor (ProGRP) is a bioactive precursor of GRP and might play an important role as an emerging tumor marker in early cancer diagnosis. It might also be abnormal in the nonmalignant disease and renal function abnormalities. The present study was undertaken to investigate the changes of ProGRP levels in patients with kidney injuries, especially with chronic kidney disease (CKD), determine the upper reference intervals and clinical diagnostic value of ProGRP in CKD, and thus help oncologists in interpreting ProGRP levels and making clinical judgments of malignances.

Pt-LIS1 participates nuclear deformation and acrosome formation via regulating Dynein-1 during spermatogenesis in Portunus trituberculatus.

Spermatogenesis involves complex dynamic mechanisms. Dynein-1 is a key carrier in cellular cargo transport, participating in nuclear deformation and acrosome formation during spermatogenesis. However, the regulatory mechanisms of Dynein-1 during cargo transport remain unknown.

Optimizing HIV testing: Comparing diagnostic signatures and assay performance in ART-treated and general screening populations.

Introduction: Accurate and early HIV detection is crucial for improving outcomes and controlling transmission. This study compares HIV marker patterns and evaluates detection assay performance in general screening and ART-treated populations to enhance diagnostic accuracy and public health.

Methods: A total of 196 blood donor samples that were initially reactive in blood center screening were collected across 17 provinces in China, along with 126 ART samples from people living with HIV (PLWH).

The U-Shape Association Between Noise and Individual Depression: Nationwide Longitudinal Evidence from Three Waves of CHARLS.

Depression is a common mental disorder formed by a combination of various factors. Existing researches have already demonstrated that noise indeed impacts the level of depression, but their results were inconsistent. To reconcile seemingly contradictory findings, this study aims to investigate how noise affects individual depression using big data mining and analysis techniques.

Multifunctional injectable hydrogel with self-supplied HS release and bacterial inhibition for the wound healing with enhanced macrophages polarization via interfering with PI3K/Akt pathway.

Hydrogen sulfide (HS) gas therapy is beneficial for accelerating wound healing and alleviating the inflammatory process, but is seriously hindered by insufficient delivery and unsustainable release in vivo. This study presents a multifunctional injectable hydrogel, OC@ε-PL-SATO, composed of oxidized hyaluronic acid and N-acetylcysteine (NAC) as an initiator, carboxymethyl chitosan and S-aroylthiooxime modified ε-Poly-(l-lysine) (ε-PL-SATO). ε-PL-SATO is a NAC-responsive HS donor.

Identification of a Novel QTL on LG16 Associated with Acute Salt Tolerance in Red Tilapia (Oreochromis spp.) Using GWAS.

Culturing saline tilapia has become a new trend in the aquaculture due to the scarcity of freshwater resources. In this study, the genetic basis controlling for salt tolerance were investigated by using a ddRAD-seq-based GWAS in 288 individuals with extreme salt tolerant traits from half-sib families of red tilapia. 12 genome-wide significant SNPs and 6 chromosome-wide significant SNPs associated with acute salt tolerance were identified.

Photocontrolled Bionic Micro-Nano Hydrogel System used Novel Functional Strategy for Cell Delivery and Large-Scale Corneal Repair.

Reproducing the microstructure of the natural cornea remains a significant challenge in achieving the mechanical and biological functionality of artificial corneas. Therefore, the development of cascade structures that mimic the natural extracellular matrix (ECM), achieving both macro-stability and micro-structure, is of critical importance. This study proposes a novel, efficient, and general photo-functionalization strategy for modifying natural biomaterials.

Long-term Clinical outcomes and Optimal Treatment Approaches of Degenerative Cervical Spondylosis: A 12-year Multicenter Retrospective Cohort Study.

Study Design/setting: A retrospective cohort study.

Objective: To compare long-term outcomes and complications of cervical disc replacement (CDR) and anterior cervical discectomy and fusion (ACDF) with cage-plate constructs (CPC) and stand-alone (SA) cages in treating degenerative cervical spondylosis.

Summary Of Background Data: ACDF is commonly used for cervical radiculopathy but may increase adjacent segment degeneration (ASD).

Cell-Type Specific miRNA Regulatory Network Responses to ABA Stress Revealed by Time Series Transcriptional Atlases in Arabidopsis.

In plants, microRNAs (miRNAs) participate in complex gene regulatory networks together with the transcription factors (TFs) in response to biotic and abiotic stresses. To date, analyses of miRNAs-induced transcriptome remodeling are at the whole plant or tissue levels. Here, Arabidopsis's ABA-induced single-cell RNA-seq (scRNA-seq) is performed at different stages of time points-early, middle, and late.

Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives.

Osteoarthritis (OA) is one of the leading causes of disability worldwide, characterized by a complex pathological process involving cartilage degradation, synovial inflammation, and subchondral bone remodeling. In recent years, ferroptosis, a form of programmed cell death driven by iron-dependent lipid peroxidation, has been recognized as playing a critical role in the onset and progression of OA. Investigating the molecular mechanisms of ferroptosis and its involvement in OA may offer novel strategies for diagnosing and treating this disease.

Effects of Mental Disorders on Fibromyalgia Mediated by Insomnia: A Mendelian Randomization Study.

Background: This study employed Mendelian randomization (MR) analysis to confirm the causal effects of mental disorders on fibromyalgia.

Methods: The summary data for exposures, mediator, and outcome were extracted from the GWAS catalog project, IEU openGWAS project, and Finn biobank database. Significantly associated and independent single-nucleotide polymorphisms (SNPs) meeting the criteria of p < 5×10-8, r2 < 0.

Immunization with the NcMYR1 gene knockout strain effectively protected C57BL/6 mice and their pups against the challenge.

is an important protozoan parasite that causes abortion in cattle and nervous system dysfunction in dogs. No effective drugs and vaccines for neosporosis are available. Further elucidation of proteins related to virulence will provide potential candidates for vaccine development against neosporosis.

Pilot Surveillance of , , and Among Chinese Blood Donors - Xinjiang, Inner Mongolia, and Heilongjiang PLADs, China, 2022-2023.

What Is Already Known About This Topic?: Recently, tick-borne pathogens transmitted through blood transfusions have posed new risks to blood safety.

What Is Added By This Report?: We developed a quality control system for nucleic acid testing (NAT) for , , and , evaluated five Triplex-NAT kits, and conducted external quality assessments of blood centers. This study screened 92,700 blood donors from Heilongjiang, Inner Mongolia, and Xinjiang provincial-level administrative divisions during 2022-2023.

Effects of Kitchen Cooking Height on Upper Limb Muscle Activation, Posture, and Perceived Discomfort of Chinese Older and Young Women.

Inappropriate kitchen cooking height may lead to uncomfortable and muscle fatigue. This study aims to compare the effects of kitchen cooking height on upper limb muscle activation, posture, and perceived discomfort among different age groups. Fifteen older women and fifteen young Chinese women each completed three consecutive 20 s simulated cooking tasks at five different heights.

Ribosomal proteins in hepatocellular carcinoma: mysterious but promising.

Ribosomal proteins (RPs) are essential components of ribosomes, playing a role not only in ribosome biosynthesis, but also in various extra-ribosomal functions, some of which are implicated in the development of different types of tumors. As universally acknowledged, hepatocellular carcinoma (HCC) has been garnering global attention due to its complex pathogenesis and challenging treatments. In this review, we analyze the biological characteristics of RPs and emphasize their essential roles in HCC.

Enzyme Tunnel Dynamics and Catalytic Mechanism of Norcoclaurine Synthase: Insights from a Combined LiGaMD and DFT Study.

This study conducts a systematic investigation into the catalytic mechanism of norcoclaurine synthase (NCS), a key enzyme in the biosynthesis of tetrahydroisoquinolines (THIQs) with therapeutic applications. By integration of LiGaMD and DFT calculations, the reaction pathway of NCS is mapped, providing detailed insights into its catalytic activity and selectivity. Our findings underscore the critical role of E103 in substrate capture and reveal the hitherto unappreciated influence of nonpolar residues M183 and L76 on tunnel dynamics.

mTOR Signaling: Roles in Hepatitis B Virus Infection and Hepatocellular Carcinoma.

Currently, chronic hepatitis B virus infection is still one of the most serious public health problems in the world. Though current strategies are effective in controlling infection and slowing down the disease process, it remains a big challenge to achieve a functional cure for chronic hepatitis B in a majority of patients due to the inability to clear the cccDNA pool. The mammalian target of rapamycin (mTOR) integrates nutrition, energy, growth factors, and other extracellular signals, participating in gene transcription, protein translation, ribosome synthesis, and other biological processes.

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Alleviate Nuclear Pulposus Cells Degeneration Through the miR-145a-5p/USP31/HIF-1α Signaling Pathway.

Bone marrow mesenchymal stem cell (BMSC)-derived exosomes possess therapeutic potential against degenerative diseases. This study aimed to investigate the effects of BMSC-derived exosomes on intervertebral disc degeneration (IVDD) and explore the underlying molecular mechanisms. Through transcriptome sequencing and histological analysis, we observed a significant increase in HIF-1α expression in degenerative nucleus pulposus (NP) tissues.

Savior or saboteur? A nationwide study on digital economy and depression in China.

The regional boom in digital economy has provided people with remote conversations and socialization while reducing the risk of depression. This study aims to elucidate whether regional digital economy can be a savior for individual depression. The multi-source dataset collects 11,845 individuals from the China Health and Retirement Longitudinal Study 2018 (CHARLS), with the combination of corresponding regional data from China City Statistical Yearbooks.

Calcium transfer from the ER to other organelles for optimal signaling in .

Ca signaling in cells begins with the opening of Ca channels in either the plasma membrane (PM) or the endoplasmic reticulum (ER) and results in a dramatic increase in the physiologically low (<100 nM) cytosolic Ca level. The temporal and spatial Ca levels are well regulated to enable precise and specific activation of critical biological processes. Ca signaling regulates pathogenic features of apicomplexan parasites like which infects approximately one-third of the world's population.

Tuning Zn-ion de-solvation chemistry with trace amount of additive towards stable Aqueous Zn anodes.

Aqueous Zn-ion batteries (AZIBs) have attracted widespread attention due to their intrinsic safety, cost-effectiveness. However, active HO in the solvated ions [Zn(HO)] continuously migrate to the Zn surface to trigger hydrogen evolution reaction (HER) and accelerate Zn corrosion. Herein, Zn dendrites and the related by-products have been successfully inhibited by using trace amounts of Nitrilotriacetic acid (NTA).