Publications by authors named "Le Bu"
Purpose: This study aimed to investigate the association of the triglyceride-glucose index (TyG) and its related parameters with the risk of hyperuricemia in patients with obesity of different sexes.
Patients And Methods: In this cross-sectional study, a total of 951 patients with obesity were included. They were divided into two groups based on their serum uric acid levels, and separate analyses were conducted for males and females.
A Single Pelvic Fibrous Tumor Associated With Doege-Potter Syndrome: A Case Study.
Case Rep Endocrinol
October 2024
Doege-Potter syndrome (DPS) is a very rare paraneoplastic condition that is marked by hypoglycemia brought on by a solitary fibrous tumor rather than an islet cell tumor. Soft tissue neoplasms termed as solitary fibrous tumors (SFTs) are rare and these tumors vary in the site of origin, from the pleural cavity, mediastinum, pericardium, retroperitoneal spaces, liver, thyroid, orbit, bladder, intestines, and soft tissues, while pelvic-derived fibrous tumors are incredibly unusual. There are currently extremely few documented cases and literature reviews both domestically and internationally.
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- The study investigates how different types of pancreatic fat are linked to the risk of developing type 2 diabetes mellitus (T2DM) in overweight or obese individuals.
- Researchers analyzed a total of 104 patients, categorizing them based on their glucose tolerance status and using advanced MRI techniques to measure various pancreatic fat types.
- Findings suggest that intra-lobular pancreatic fat, particularly in the head, body, and tail of the pancreas, may serve as an important independent risk factor for T2DM, outperforming other fat measures in diagnosing glucose metabolism issues.
Objective: An alterable risk factor for hyperuricemia is obesity. Additionally, obese people may have a moderate form of acquired resistance to thyroid hormones. Thyrotropin, thyroid hormones, and obesity all interact subtly.
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- - The study addresses the challenges in accurately recognizing food images, which are important for nutrition monitoring and food recommendations, due to issues like complex backgrounds and varying characteristics within food categories.
- - The authors propose a new method that combines transfer learning, using pre-trained convolutional neural network models (like VGG19 and ResNet50), with ensemble learning for improved accuracy in recognizing food images.
- - Experimental results show that the ensemble model achieved the highest accuracy of 96.88%, outperforming individual models, indicating that this approach is effective and practical for food image recognition.
Sex-dependent impact of obesity on aggressiveness of papillary thyroid cancer.
Hormones (Athens)
June 2024
Purpose: To investigate the impact of body mass index (BMI) on the aggressiveness of papillary thyroid cancer (PTC).
Methods: A total of 1720 PTC patients with total thyroidectomy or lobectomy, from January 2017 to April 2020, were retrospectively evaluated. Based on BMI, they were divided into two groups, as follows: control (CON, < 24 kg/m) and overweight and obesity (OB, ≥ 24 kg/m), each sex being analyzed separately.
Article Synopsis
- The study examines the relationship between serum superoxide dismutase (SOD) levels and thyroid function in obese patients before and after laparoscopic sleeve gastrectomy (LSG).
- Patients were divided into two groups based on SOD levels, and results showed that higher SOD levels correlated with better thyroid hormone profiles and lower body mass index (BMI).
- After LSG, SOD and free thyroxine (FT4) levels increased while total thyroid hormones decreased, indicating that higher SOD levels may help protect against subclinical hypothyroidism in obese individuals.
Article Synopsis
- Research highlights the role of liver fatty acid binding protein 1 (FABP1) in managing nonalcoholic fatty liver disease (NAFLD) but lacks clarity on its dynamic regulation during metabolic disorders.
- * A study revealed that Derlin-1, which interacts with FABP1, negatively affects FABP1's expression through ubiquitination, contributing to reduced lipid accumulation in liver cells.
- * Overexpressing Derlin-1 showed positive effects such as decreased liver fat and weight gain, suggesting it could be a promising therapeutic target for treating NAFLD.
Objective: To explore the predictors of menstrual recovery in polycystic ovary syndrome (PCOS) women with obesity following laparoscopic sleeve gastrectomy (LSG).
Methods: A total of 88 PCOS patients with obesity and 76 control patients with obesity aged 18-45 years were enrolled between May 2013 and December 2020. PCOS was diagnosed using the Rotterdam diagnostic criteria (2003).
Association between liver-type fatty acid-binding protein and hyperuricemia before and after laparoscopic sleeve gastrectomy.
Front Endocrinol (Lausanne)
October 2022
Article Synopsis
- Liver-type fatty acid-binding protein (FABP1) is linked to metabolic issues, and this study explores its connection to hyperuricemia in obese patients undergoing weight loss surgery.
- The study found that FABP1 levels were significantly higher in obese individuals with high uric acid levels, and this increase was correlated with uric acid levels before surgery.
- After laparoscopic sleeve gastrectomy, FABP1 and uric acid levels decreased in both groups, but the decrease was more pronounced in those with hyperuricemia, suggesting FABP1 may be a risk factor for this condition in obesity.
Article Synopsis
- Metabolic dysfunction associated fatty liver disease (MAFLD) is linked to obesity and chronic inflammation, with high-sensitive C-reactive protein (hsCRP) used as a marker for diagnosis.
- A study involving 393 obese patients determined the relationship between hsCRP levels and the severity of liver conditions, categorizing patients into MAFLD and non-MAFLD groups.
- Results indicated that higher hsCRP levels were significantly associated with increased severity of liver steatosis and fibrosis in MAFLD patients, suggesting hsCRP could serve as a useful indicator for assessing liver health in obesity.
Nonalcoholic steatohepatitis (NASH) is a state of simple steatosis that progresses to inflammation and liver injury accompanied by ferroptosis. Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in hepatic steatosis and iron regulation. However, the direct impact of BMP4 on NASH remains unclear.
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- Metabolic-associated fatty liver disease (MAFLD) is a growing global issue linked to prolactin (PRL), leading researchers to investigate its connection to MAFLD in type 2 diabetes mellitus (T2DM) patients.
- A study with 724 adults assessed the relationship between serum PRL levels and MAFLD risk, utilizing methods like FibroScan for liver analysis and stratifying patients based on PRL levels.
- Results showed significant gender differences, with females exhibiting a J-shaped association between PRL levels and MAFLD risk, while no such correlation was found for males, suggesting PRL's role in MAFLD progression varies by gender.
Article Synopsis
- - Bariatric surgery is an effective treatment for obesity, but not all patients achieve significant weight loss, leading researchers to study the role of serum lipocalin-2 (LCN2) levels in predicting weight loss success after surgery.
- - The study involved 450 patients, focusing on 74 who met specific criteria, measuring parameters like LCN2, thyroid function, and other metabolic measures at 3 months and 1 year post laparoscopic sleeve gastrectomy (LSG).
- - Findings revealed that higher preoperative LCN2 levels, waist circumference, and glycated hemoglobin were strong predictors of achieving 75% excess weight loss one year post-surgery, leading to the creation of a new predictive index for
Background: Lipocalin-2 (LCN2) has a critical effect on obesity as well as its associated comorbidities. The present study focused on analyzing serum LCN2 levels of obese patients with nonalcoholic fatty liver disease (NAFLD) and on determining relationship of hepatic steatosis improvement with LCN2 levels after laparoscopic sleeve gastrectomy (LSG).
Methods: This work enrolled ninety patients with obesity and NAFLD.
Gastric mucosal injury is a less well known complication of obesity. Its mechanism remains to be further elucidated. Here, we explored the protective role of lipocalin 2 (LCN2) against endoplasmic reticulum stress and cell apoptosis in gastric mucosa in patients and mice with obesity.
View Article and Find Full Text PDFTo investigate the risk-stratifying utility of tumor size and a threshold for further stratification on cancer-specific mortality of thyroid cancer (TC) patients in stage IVB. One thousand three hundred and forty-five patients (620 males and 725 females) with initial distant metastasis over 55 years between 2004 and 2016 from Surveillance, Epidemiology, and End Results databases were investigated, with a median follow-up time of 23 months [interquartile range (IQR), 5-56 months] and a median age of 70 years (IQR, 63-77 years). TC-specific mortality rates were calculated under different classifications.
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- Islet beta-cell dysfunction is a major contributor to diabetes, and previous studies indicate that miRNA plays a role in regulating beta-cell function.* -
- This research focused on the impact of miR-383 on beta-cells using both lab experiments and animal models, showing that miR-383 can reduce cell apoptosis and oxidative stress caused by high glucose levels.* -
- The findings suggest that miR-383 works by targeting specific genes (TLR4 and ApoC3), leading to improved pancreatic function and decreased diabetes symptoms in mice.*
J-shaped association between fasting blood glucose levels and COVID-19 severity in patients without diabetes.
Diabetes Res Clin Pract
October 2020
Article Synopsis
- A study involving 293 COVID-19 patients without diabetes aims to understand how fasting blood glucose (FBG) levels affect disease progression and mortality risk from COVID-19.
- The research finds a significant association between FBG levels and the likelihood of developing severe or critical COVID-19 conditions, using multivariate logistic regression to analyze the data.
- Results show a J-shaped relationship between FBG levels and risk, indicating that the optimal range for lower risk is between 4.74 and 5.78 mmol/L, with risks increasing significantly outside of that range.
It was reported that either orexigenic neuropeptide galanin or anorexigenic hormone leptin caught benefit insulin sensitivity through increasing the translocation of glucose transporter 4 (GLUT4) in patients with diabetes. To date, it is unknown whether galanin can potentiate the effect of leptin on alleviation of insulin resistance. Therefore, in the current study we sought to assess the combined effect of central leptin and galanin on insulin resistance in the adipose tissues of type 2 diabetic rats.
View Article and Find Full Text PDFObjective: The role of liver fatty acid-binding protein (FABP1) in obesity is presently unclear. We investigated the association of FABP1 with obesity and the changes noted after laparoscopic sleeve gastrectomy (LSG) in a Chinese population.
Methods: The cross-sectional analysis included 187 individuals: 65 had normal weight (18.
Background: Although the results of our and other studies show that baicalin can enhance glucose uptake and insulin sensitivity in skeletal muscle and adipocytes of mice, the specific metabolic contribution of baicalin on hepatic insulin resistance and gluconeogenic activity is still unclear.
Purpose: The aim of this study is to investigate whether baicalin is involved in regulation of hepatic insulin resistance and gluconeogenic activity and its underlying mechanisms.
Study Design/methods: In the present study, high-fat diet-induced obese mice were given 50 mg/kg baicalin intraperitoneally (i.