A Novel Crosslinking Approach for Biomanufacturing of a Collagen-Based Skin Dermal Template.

Third-degree burns result in extensive damage to the skin's epidermal and dermal layers, with limited treatment options available. Currently, xenogeneic collagen-based skin grafts are used as scaffolds to integrate into the wound bed and provide a template for neodermis formation. Existing commercial products like Integra dermal templates rely on a time-consuming and variable dehydrothermal (DHT) crosslinking process.

Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic.

Bone morphogenetic protein 2 (BMP-2) is an osteoinductive protein and a potent inducers of bone formation, playing an essential role during bone fracture repair. Heparan sulfate (HS), a highly charged and linear polysaccharide, is known to interact with and enhance BMP-2 bioactivity. Despite showing potential as a potent adjuvant of the endogenous bone healing response, commercially available HS is derived from animal sources which are less desirable when considering translation into the clinic.

Innovative Approach to Severe Esthetic Zone Trauma: Integrating Root Submergence With Guided Bone Regeneration.

Objective: Acute traumatic defects in the esthetic zone pose a significant challenge in dental implant rehabilitation, requiring innovative techniques to achieve optimal functional and esthetic outcomes. This article investigates the use of a novel combination of root submergence and guided bone regeneration (GBR) to address these defects. The goal is to evaluate the potential of this integrated approach for achieving predictable bone regeneration and long-term tissue stability.

Bilateral dens evaginatus and associated cystic pathology: An unusual case report.

Dens evaginatus (DE) presents a clinical conundrum due to its fragility and propensity to cause pulpal and periapical complications. Clinicians should heed the presence of DE during clinical examinations and avoid unnecessary intervention.

Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2.

Heparan sulfate (HS) is a glycosaminoglycan (GAG) found throughout nature and is involved in a wide range of functions including modulation of cell signalling via sequestration of growth factors. Current consensus is that the specificity of HS motifs for protein binding are individual for each protein. Given the structural complexity of HS the synthesis of libraries of these compounds to probe this is not trivial.

Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis.

It is challenging to regenerate periodontal tissues fully. We have previously reported a heparan sulfate variant with enhanced affinity for bone morphogenetic protein-2, termed HS3, that enhanced periodontal tissue regeneration in a rodent model. Here we seek to transition this work closer to the clinic and investigate the efficacy of the combination HS3 collagen device in a non-human primate (NHP) periodontitis model.

The Aesthetic Contour Graft - Enhancing peri-implant soft tissue contours and pontic sites with guided bone regeneration.

Objective: In this article, we will discuss strategies for enhancing peri-implant soft tissue contours and pontic sites with hard tissue augmentation.

Clinical Consideration: One of the keys to the esthetic illusion of an implant-supported restoration is to create an ideal emergence profile. A critical part of any emergence profile is based on the height and thickness of the tissue surrounding the restoration and whether there are any defects in this tissue.

Managing a Deficient Site: How to Augment Prior to Implant Placement in the Esthetic Zone.

The loss of teeth can result in moderate alveolar ridge shrinkage. This bone loss is exacerbated if there are pre-existing endodontic pathologies and/or periodontal disease. Achieving an ideal esthetic outcome is challenging when moderate bone and soft-tissue defects exist.

Comparative evaluation of implant stability quotient trends, crestal bone loss and survival of photofunctionalised and untreated dental implants: A split-mouth randomised controlled clinical trial.

Purpose: To evaluate the crestal bone loss and implant stability quotient trends of photofunctionalised versus untreated implants.

Materials And Methods: A total of 34 patients (age 46.94 ± 12.

Anatomic variations of the osteomeatal complex and its relationship to patency of the maxillary ostium: A retrospective evaluation of cone-beam computed tomography and its implications for sinus augmentation.

Aim: The aim of this study is to determine the incidence of obliterated osteomeatal complex (OMC) due to the presence of anatomic variants.

Settings And Design: Retrospective Study.

Materials And Methods: In this retrospective study, a total of 71 patients, 34 males and 37 females, aged 35-65 years were included in the study.

Ultrasound and CBCT analysis of blood flow and dimensions of the lingual vascular canal: A case control study.

Objective: To assess the correlation between the diameter of the mandibular lingual vascular canal (MLVC) as determined on CBCT examination to blood flow and arterial diameter as determined by ultrasound Doppler analysis (USG) in dentate and edentulous patients.

Methods: 20 subjects were equally distributed into two groups based on the status of their dentition. Group 1 included dentate subjects (DE) and Group 2 included edentulous subjects (ED).

Immunomodulatory potential of extracts, fractions and pure compounds from Phyllanthus amarus and Psidium guajava on striped catfish (Pangasianodon hypophthalmus) head kidney leukocytes.

This study aimed to identify major phytochemical constituents, as well as compare the immunomodulatory effects of Psidium guajava L. and Phyllanthus amarus Schun and Thonn crude ethanol extracts and their fractions on striped catfish (Pangasianodon hypophthalmus) head kidney leukocytes (HKLs). Moreover, pure constituents were also investigated for their effects on those cells: hypophyllanthin, identified as a major constituent of P.

Single or Combined Dietary Supply of and Extracts Differentially Modulate Immune Responses and Liver Proteome in Striped Catfish ().

Guava L (Pg) and bhumi amla Schum. et Thonn (Pa) are well-known plants in traditional medicine. However, the capacity of these plants for improving the immune system of aquatic species has received less attention so far.

Successive Reimplantation of Dental Implants Into Sites of Previous Failure.

Purpose: To evaluate the survival rates of dental implants that had been reimplanted in sites of previous failure, including first, second, and third reimplantations, and investigate the various factors that could affect the reimplantation outcomes.

Materials And Methods: All dental implants placed in sites of previous implant failure were identified, including first, second, and third reimplantations. The survival rates were assessed, and epidemiologic and clinical data were collected and analyzed to evaluate the effects on reimplantation survival.

An Objective Assessment of Orthognathic Surgery Patients.

Objectives: To retrospectively assess malocclusions, skeletal relationships and the functional needs of orthognathic patients treated in a University teaching hospital.

Subjects And Methods: This study used clinical records of 100 consecutive patients [51 female, 49 males, mean (SD) age =21.5 (2.

Indirect Sinus Augmentation With and Without the Addition of a Biomaterial: A Randomized Controlled Clinical Trial.

Purpose: The aim of this study was to compare the results of indirect sinus augmentation with and without the addition of a biomaterial.

Materials And Methods: Thirty patients aged 40 to 60 years participated in this randomized controlled clinical trial. After closed sinus lift operation, patients were randomly and equally divided into blood clot control and acemannan sponge graft groups.

Screening of immuno-modulatory potential of different herbal plant extracts using striped catfish (Pangasianodon hypophthalmus) leukocyte-based in vitro tests.

Many medicinal plants have been shown to possess biological effects, including immuno-modulatory activities on human and other mammals. However, studies about the potential mechanisms of plant extracts on the humoral and tissular immunities in fish have received less attention. This study aimed to screen the immunestimulating properties of 20 ethanol plant extracts on striped catfish Pangasianodon hypophthalmus leukocytes.

Plant extract-based diets differently modulate immune responses and resistance to bacterial infection in striped catfish (Pangasianodon hypophthalmus).

A feeding trial was performed to compare the effects of five ethanol herbal extracts (bhumi amla, Phyllanthus amarus Schum and Thonn [Pa]; guava, Psidium guajava L. [Pg]; sensitive plant, Mimosa pudica L. [Mp]; neem, Azadirachta indica A.

A polycaprolactone-β-tricalcium phosphate-heparan sulphate device for cranioplasty.

Background: Cranioplasty is a surgical procedure used to treat a bone defect or deformity in the skull. To date, there is little consensus on the standard-of-care for graft materials used in such a procedure. Graft materials must have sufficient mechanical strength to protect the underlying brain as well as the ability to integrate and support new bone growth.

Whole Genome Sequencing of a Vietnamese Family from a Dioxin Contamination Hotspot Reveals Novel Variants in the Son with Undiagnosed Intellectual Disability.

Although it has been a half-century since dioxin-contaminated herbicides were used to defoliate the landscape during the Vietnam War, dioxin contamination "hotspots" still remain in Vietnam. Environmental and health impacts of these hotspots need to be evaluated. Intellectual disability (ID) is one of the diseases found in the children of people exposed to the herbicides.

Multi-criteria Mapping of Stakeholders' Viewpoints in Five Southeast Asian Countries on Strategies to Reduce Micronutrient Deficiencies Among Children and Women of Reproductive Age: Findings from the SMILING Project.

Background: Despite scientific evidence on the potential impact or importance of specific interventions to improve micronutrient status of vulnerable groups, political commitment and extensive support from national stakeholders is paramount to support introduction and implementation of these interventions at national level. In order to develop efficient nutritional strategies to improve the micronutrient status of children < 5 years of age and women of reproductive age that will be supported by a wide range of stakeholders, a better understanding of viewpoints on the nutrition politics and strategies is necessary. Multi-criteria mapping (MCM) was successfully used to assess the stakeholder's viewpoint in a wide variety of contexts since the late 1990s.

Realistic Food-Based Approaches Alone May Not Ensure Dietary Adequacy for Women and Young Children in South-East Asia.

Objectives Micronutrient deficiencies, in southeast Asia (SE Asia), remain a public health challenge. We evaluated whether promoting the consumption of locally available nutritious foods, which is a low-risk micronutrient intervention, alone can ensure dietary adequacy, for women of reproductive age and 6-23 m old children. Methods Representative dietary data from Cambodia, Indonesia, Lao PDR, Thailand and Vietnam were analysed using linear programming analysis to identify nutrients that are likely low in personal food environments (problem nutrients), and to formulate food-based recommendations (FBRs) for three to six target populations per country.