Aerobic synthesis of -sulfonylamidines mediated by N-heterocyclic carbene copper(I) catalysts.

A new catalytic strategy for the one-pot synthesis of -sulfonylamidines is described. The cationic copper(I) complexes were found to be highly active and efficient under mild conditions in air and in the absence of solvent. A copper acetylide is proposed as key intermediate in this transformation.

Hydrophenoxylation of internal alkynes catalysed with a heterobimetallic Cu-NHC/Au-NHC system.

A straightforward method for the hydrophenoxylation of internal alkynes, using N-heterocyclic carbene-based copper(i) and gold(i) complexes, is described. The heterobimetallic catalytic system proceeds via dual activation of the substrates to afford the desired vinylether derivatives. This methodology is shown to be highly efficient and tolerates a wide range of substituted phenols and alkynes.

Homoleptic and heteroleptic bis-NHC Cu(I) complexes as carbene transfer reagents.

Homo- and heteroleptic bis-NHC copper(I) complexes have been efficiently used as carbene transfer reagents to Au and Pd. The simple and straightforward procedure allows for the synthesis of well-known gold complexes as well as novel cationic bis-NHC Pd(II) species.

Copper N-Heterocyclic Carbene Complexes As Active Catalysts for the Synthesis of 2-Substituted Oxazolines from Nitriles and Aminoalcohols.

The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper-NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than those of previously reported methods.

N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2.

The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(i) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.

First Report of Fusarium equiseti Causing Damping-Off Disease on Aleppo Pine in Algeria.

The Aleppo pine (Pinus halepensis Mill.) is a conifer native to the Mediterranean region. In 2008 and 2009, a survey of Aleppo pine seedling diseases was performed in three forest nurseries from Relizane, Sidi Bel Abbes, and Tlemcen provinces in northwestern Algeria.

A cooperative Pd-Cu system for direct C-H bond arylation.

A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.

First Report of Fusarium chlamydosporum Causing Damping-Off Disease on Aleppo Pine in Algeria.

The Aleppo pine (Pinus halepensis Mill.) is a conifer native to the Mediterranean region. In 2008 and 2009, a survey of Aleppo pine seedling diseases was performed in three forest nurseries from the Relizane, Sidi Bel Abbes, and Tlemcen departments in northwestern Algeria.

First Report of Globisporangium ultimum Causing Pythium Damping-Off on Aleppo Pine in Algeria, Africa, and the Mediterranean Region.

Globisporangium ultimum (Trow) Uzuhashi, Tojo & Kakish. (syn. Pythium ultimum Trow, syn.

First Report of Fusarium redolens as a Causal Agent of Aleppo Pine Damping-Off in Algeria.

Aleppo pine (Pinus halepensis Mill.) is a common native coniferous tree in the natural forests of the Mediterranean region. In 2008 and 2009, a survey of Aleppo pine seedling diseases was performed in three forest nurseries from Relizane, Sidi Bel Abbes, and Tlemcen departments in northwestern Algeria.

First Report of Fusarium acuminatum Causing Damping-Off Disease on Aleppo Pine in Algeria.

The Aleppo pine (Pinus halepensis Mill.) is a conifer native to the Mediterranean region. In autumn and spring of 2008 to 2009, a survey of Aleppo pine seedling diseases was carried out in three forest nurseries from the Relizane, Sidi Bel Abbes, and Tlemcen departments in northwestern Algeria.

Rituximab induction immunotherapy for first-line low-tumor-burden follicular lymphoma: survival analyses with 7-year follow-up.

Background: The purpose of this study was to report long-term results of rituximab induction monotherapy in patients with low-tumor-burden follicular lymphoma (LTBFL).

Patients And Methods: Of 49 first-line LTBFL patients who received weekly doses of rituximab (375 mg/m(2)), 46 have been followed with a long-term analysis of clinical and molecular responses.

Results: Best clinical response (at any staging within a year following treatment) was 80%, 24 (52%) patients had complete or unconfirmed complete response, 13 (28%) had partial response and 9 (20%) had stable or progressive disease.

A 4-weekly course of rituximab is safe and improves tumor control for patients with minimal residual disease persisting 3 months after autologous hematopoietic stem-cell transplantation: results of a prospective multicenter phase II study in patients with follicular lymphoma.

Background: This study explored the efficacy and safety of rituximab as treatment of clinical or molecular residual disease after autologous stem-cell transplantation (ASCT) in follicular lymphoma (FL).

Patients And Methods: Forty patients with CD20+ FL and clinically (group A, n = 14) or clono-specific PCR-detectable (group B, n = 25) residual disease persisting 3 months after ASCT received rituximab 375 mg/m² once weekly for 4 weeks.

Results: Response rate at day 50 was 36% [90% confidence interval (CI) 15-61] in group A (World Health Organization criteria) and 52% (90% CI 34-70) in group B (conversion PCR-undetectable status to undetectable status).

Decarboxylation of aromatic carboxylic acids by gold(I)-N-heterocyclic carbene (NHC) complexes.

A recently isolated gold(I) complex, [Au(IPr)(OH)], permits the transformation of carboxylic acids to the corresponding decarboxylated gold(I)-aryl complex without the use of silver co-catalyst under mild reaction conditions.

[Profile of tobacco use among the teachers of Sousse, Tunisia].

Objective: To examine the prevalence of tobacco use among the teachers in the region of Sousse (Tunisia) and to identify the factors, which determine this behavior.

Patients And Methods: It is a transactional study; using a self-administered and pre-tested questionnaire to 800 teachers.

Results: The population being studied was made up of 739 teachers including 50.

Evaluation of the diagnostic value of measuring IgG, IgM, and IgA antibodies to mycobacterial A60 antigen in active tuberculosis.

The purpose of the present study was to evaluate the clinical usefulness of detection of serum immunoglobulin A (IgA), IgG, and IgM antibodies raised against the mycobacterial A60 antigen for the diagnosis and discrimination of active tuberculosis (TB) from other pulmonary diseases. Three commercially available ELISA kits (IgA, IgG, and IgM) (ANDA Biologicals, Strasbourg, France) were evaluated simultaneously in 246 serum samples from 3 groups of patients: group I, 171 patients with active TB (128 pulmonary TB and 43 extrapulmonary TB); group II, 73 patients with pulmonary non-TB diseases; and group III, 2 leprosies patients. The sensitivities of tests ranged from 31.

Rapid detection of immunoglobulin G against Mycobacterium tuberculosis antigens by two commercial ELISA kits.

Setting: Tunisia.

Objective: To assess the clinical usefulness of the commercial Pathozyme-Myco G (Myco G) and Pathozyme TB complex plus (Patho) enzyme-linked immunosorbent assay (ELISA) kits for the rapid diagnosis of active tuberculosis (TB) and to distinguish between active TB and non-TB pulmonary diseases in Tunisian patients.

Design: Immunoglobulin G mediated humoral immune response against mycobacterial antigens (38 kDa and lipoarabinomannan, Myco G; 16 and 38 kDa, Patho) was evaluated in a group of active TB patients (128 smear-positive pulmonary and 33 extra-pulmonary samples) and in a control group (107 patients with non-tuberculous lung disease and two with leprosy).

[Behaviours and needs for health of secondary-school-adolescents in Sousse (Tunisia)].

It was a descriptive study bearing on a probabilistic sample of one-degree cluster composed of 685 adolescents studying in six secondary state schools in Sousse, during 1998-1999 school year. The facts had been collected through an anonymous and self administrated questionnaire. 23.

[Victims of violence in urban secondary schools in Sousse (Tunisia)].

Most often epidemiologic studies of violence during adolescence focus on aspects related to the perpetrator. The adolescent victims of violence are certainly at least as numerous, but too little is known about them. Our aim was to estimate the extent of this social phenomenon and to identify its various forms, through a descriptive, cross-sectional study of a sample of 685 teenagers (409 girls and 276 boys) from six public high schools in Sousse in 1999.

[School retardation in a suburban community of Tunisian Sahel].

This study tries to assess the prevalence of the school retardation in a suburban community of the Tunision Sahel, to identify its determinants factors and to propose a preventive strategy. It is a transverse investigation having interested 540 registered pupils at the 6th year in six randomly chosen primary schools of Kalaa Kebira (Sousse-Tunisia). Showed that the prevalence of the school retardation is 29%.

[Smoking among school children in Sousse, Tunisia].

In order to study smoking habits of children and adolescents from Sousse in Tunisia, we undertook an epidemiological survey on a representative sample of 1569 pupils aged between 13 and 19 years with a global answer rate of 95,4%. The objective of the study was both to describe Tunisian adolescent smoking behaviour and also to evaluate the influence of the home environment, friends and the different socio-demographic factors on acquiring or maintaining the habit. Students were surveyed in schools using a self-administered, anonymous questionnaire.

[Study of overweight and obesity in a population of urban school children in Sousse, Tunisia].

Aim: The aim of this study was to assess the prevalence of obesity and overweight and their relationship with cardiovascular disease risk factors.

Methods: Epidemiological survey based on a representative sample of 1569 urban school children of Sousse, Tunisia.

Results: Overweight (BMI > or = 25) was significantly higher in girls (16.