Elizabeth Bagshaw: Pioneer of Canadian Women's Health.

Dr. Elizabeth Bagshaw, an esteemed figure among Canada's female physicians, devoted over seven decades to advancing obstetrics and reproductive health. She defied conventional norms by pursuing medical education and graduating from the Ontario Medical College for Women in 1905.

Stereotactic Body Radiotherapy: is less fractionation more effective in adrenal and renal malignant lesions?

Purpose: Stereotactic body radiotherapy (SBRT) has become an excellent non-invasive alternative for many patients with primary renal cell carcinoma (RCC) and adrenal malignancies (AM). The aims of this study were to analyse how tumor-, patient- and treatment-related factors may influence the outcomes and side effects of SBRT and to assess its benefits as an alternative to surgery.

Methods: This retrospective, multicenter study included 25 lesions in 23 patients treated with SBRT using different devices (LINAC, CyberKnife and Tomotherapy).

Is There an Opportunity to De-Escalate Treatments in Selected Patients with Metastatic Hormone-Sensitive Prostate Cancer?

The treatment landscape for metastatic hormone-sensitive prostate cancer continues to evolve, with systemic treatment being the mainstay of current treatment. Prognostic and predictive factors such as tumour volume and disease presentation have been studied to assess responses to different treatments. Intensification and de-escalation strategies arouse great interest, so several trials are being developed to further personalize the therapy in these populations.

Mitochondrially Targeted Gene Therapy Rescues Visual Loss in a Mouse Model of Leber's Hereditary Optic Neuropathy.

Leber's hereditary optic neuropathy (LHON) is a common mitochondrial genetic disease, causing irreversible blindness in young individuals. Current treatments are inadequate, and there is no definitive cure. This study evaluates the effectiveness of delivering wildtype human NADH ubiquinone oxidoreductase subunit 4 ) gene using mito-targeted AAV(MTSAAV) to rescue LHOH mice.

Removal of Heavy Metals from Mine Tailings in Central Chile Using Meyen, DC, and Miers ex Bertero.

Mining activities have been a part of the history of Chile since time immemorial, generating pollution and environmental liabilities. Due to the lack of regulation, many tailings are deposited close to rivers or/and on unstable ground, near which towns have been built, generally in locations with no budget for their treatment. This study tested three plant species from Northern and Central Chile to remove total chromium, nickel, and zinc from tailings: , and , which complements the few existing studies on heavy metals removal with native or endemic Chilean shrubs.

The Impact of a Group Telemedicine Program for Chronic Disease: A Retrospective Cohort Survey Study on Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder.

We present an innovative care model for telehealth by creating a video conference group telemedicine program for patients with chronic disease and discuss findings from a post-program survey that was instrumental in understanding the response to telemedicine in a group setting. All patients who attended the group telemedicine program had a diagnosis of Hypermobile Ehlers-Danlos Syndrome or Hypermobility Spectrum Disorder and were requested to complete survey responses at the close of the program. Surveys were completed anonymously and electronically by REDCap.

Long-Term Outcomes of Dose-Escalated Hypofractionated Radiotherapy in Localized Prostate Cancer.

This retrospective study aimed to provide some clinical outcomes regarding effectiveness, toxicity, and quality of life in PCa patients treated with dose-escalated moderately hypofractionated radiation therapy (HFRT). Patients received HFRT to a total dose of 66 Gy in 22 fractions (3 Gy/fraction) delivered via volume modulated arc therapy (VMAT) in 2011-2016. Treatment effectiveness was measured by the biochemical failure-free survival rate.

An Assessment of the Metal Removal Capability of Endemic Chilean Species.

In Chile, there are several abandoned mine tailing impoundments near population centers that need to be remediated. In this study, the ability of , and to remove Zn, Ni, and Cr from mine tailings was evaluated. The plants' removal efficiency, bioconcentration, and translocation factors regarding these metals were determined to assess the ability of certain endemic species from Northern and Central Chile to extract or stabilize metals.

sp. nov.: a new species of leaf-miner associated with (Asteraceae) from Southern Peru (Lepidoptera, Gracillariidae).

The southwestern Andes of Peru harbors a hidden taxonomic diversity of Lepidoptera. Here a new leaf-mining species of Gracillariidae (Lepidoptera) is described, Vargas & Cerdeña, , from a dry Andean valley of southern Peru, at 2400 m above sea level. The morphological aspects of adults (male and female) and the immature stages associated with Meyen & Walp.

Development of a Standardized Data Collection Tool for Evaluation and Management of Coronavirus Disease 2019.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ) is responsible for coronavirus disease 2019 (COVID-19), a disease that had not been previously described and for which clinicians need to rapidly adapt their daily practice. The novelty of SARS-CoV-2 produced significant gaps in harmonization of definitions, data collection, and outcome reporting to identify patients who would benefit from potential interventions.

Methods: We describe a multicenter collaboration to develop a comprehensive data collection tool for the evaluation and management of COVID-19 in hospitalized patients.

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19.

This prospective nonrandomized open-label cohort study addresses the safety and efficacy of exosomes (ExoFlo™) derived from allogeneic bone marrow mesenchymal stem cells as treatment for severe COVID-19. During April 2020, ExoFlo was provided to 24 SARS-CoV-2 polymerase chain reaction-positive patients at a single hospital center, all of whom met criteria for severe COVID-19 as well as moderate-to-severe acute respiratory distress syndrome. Patients received a single 15 mL intravenous dose of ExoFlo and were evaluated for both safety and efficacy from days 1 to 14 post-treatment.

Risk of Stroke in Patients With Patent Foramen Ovale Who Had Pulmonary Embolism.

Background: The presence of patent foramen ovale (PFO) alone does not increase the risk of ischemic stroke. Several prospective studies with a small number of patients have shown that the risk of ischemic stroke is higher in patients with PFO and pulmonary embolism (PE). We studied the association of ischemic stroke in the patients who had PFO with PE (PFOwiPE) and compared with the patients who had PFO without PE (PFOwoPE).

Risk factors and spatial relative risk assessment for influenza A virus in poultry and swine in backyard production systems of central Chile.

Backyard production systems (BPS) are a common form of poultry and swine production worldwide. The limited implementation of biosecurity standards in these operations makes BPS a potential source for the emergence of pathogens that have an impact on both animal and public health. Information regarding circulation of influenza A virus (IAV) in poultry and swine raised in BPS is scarce; particularly in South American countries.

Copper Analysis by Two Different Procedures of Sequential Extraction after Electrodialytic Remediation of Mine Tailings.

The analysis of Cu distribution in pre-treated mine tailings after electrodialytic remediation was carried out by using two methods of sequential extraction. The initial content of copper in the tailings was 1109 mg Cu/kg of dry tailing, where close to 40% of the sample in weight corresponded to a soluble fraction. The tailing was treated with a leaching solution for 24 h.

Facilitating and Inhibiting Factors for Self-Reports of Same-Gender Attraction in Cisgender Heterosexual-Identifying Women and Men.

We sought to identify psychosocial predictors of homoerotic motivations (viz., same-gender attraction) in heterosexual identifying cisgender women and men. We recruited participants from Amazon's Mechanical Turk to complete measures of (a) antipathy towards lesbians and gay men, (b) gender role beliefs, (c) felt-pressure to conform to gender stereotypes, and (d) openness to experience.

Application of a Sequential Extraction Method for Analyzing Cu Distribution in Pre-Treated Mine Tailings after Electrodialytic Remediation.

Mine tailings have been analyzed by a sequential extraction procedure after their pre-treatment with a leaching solution for 24 h and electrodialytic remediation during 15 days with a constant electric field of 2.7 V cm. Four leaching solutions were tested: H₂SO₄ + HNO₃ (2:1 vol.

Selenium removal from petroleum refinery wastewater using an electrocoagulation technique.

In the present work, an electrocoagulation technique was tested as a possible technological alternative for the treatment of selenium in wastewater from a petroleum refinery. For this purpose, a batch airlift reactor with air stirring was used. The sacrificial electrodes were made of iron to generate the necessary ferrous ions for the process.

Presence of influenza viruses in backyard poultry and swine in El Yali wetland, Chile.

In South America little is known regarding influenza virus circulating in backyard poultry and swine populations. Backyard productive systems (BPS) that breed swine and poultry are widely distributed throughout Chile with high density in the central zone, and several BPS are located within the "El Yali" (EY) ecosystem, which is one of the most important wetlands in South America. Here, 130 different wild bird species have been described, of them, at least 22 species migrate yearly from North America for nesting.

Sentinel Surveillance Detects Low Circulation of Vibrio cholerae Serotype Inaba in Haiti, 2011-2012.

Over 700,000 cases of cholera were reported in Haiti between October 2010 and February 2015. In November 2011, the Cuban Medical Team serving in Haiti established a laboratory-supported sentinel surveillance system for cholera in 10 public hospitals (one in each of Haiti's 10 departments), to estimate the proportion of hospitalized patients with cholera and detect emergence of new Vibrio cholerae serotypes. Each month, the first ten stool samples collected from patients admitted with acute watery diarrhea were studied in all hospitals involved.

Introducing the Body-QoL®: A New Patient-Reported Outcome Instrument for Measuring Body Satisfaction-Related Quality of Life in Aesthetic and Post-bariatric Body Contouring Patients.

Objective: To develop a new patient-reported outcome instrument (PRO) to measure body-related satisfaction quality of life (QoL).

Methods: Standard 3-phase PRO design was followed; in the first phase, a qualitative design was used in 45 patients to develop a conceptual framework and to create preliminary scale domains and items. In phase 2, large-scale population testing on 1340 subjects was performed to reduce items and domains.

Influence of (11)C-choline PET/CT on radiotherapy planning in prostate cancer.

Aim: To evaluate the influence of (11)C-choline PET/CT on radiotherapy planning in prostate cancer patients.

Background: Precise information on the extension of prostate cancer is crucial for the choice of an appropriate therapeutic strategy. (11)C-choline positron emission tomography ((11)C-choline PET/CT) has two roles in radiation oncology (RT): (1) patient selection for treatment and (2) target volume selection and delineation.

Assessment of sleep disturbances in patients with cancer: Cross-sectional study in a radiotherapy department.

Purpose: To explore sleep-related problems reported by patients with cancer prior to undergoing radiotherapy, and to analyse the effect of cancer severity, history of treatment and psychosomatic symptomatology on these problems.

Method: A descriptive cross-sectional study was conducted. One hundred and five patients with cancer were evaluated prior to radiotherapy.