Publications by authors named "Lazha Sharief"
Objective: To assess the efficacy of simvastatin 80 mg/day versus placebo in patients with noninfectious nonanterior uveitis receiving prednisolone ≥ 10 mg/day.
Design: Randomized, double-masked, controlled trial.
Subjects: Adult patients with noninfectious nonanterior uveitis on oral prednisolone dose of ≥ 10 mg/day.
Background: Examining the effect of antibiotic resistance, use of intravitreal antibiotics and systemic corticosteroids on visual outcome of eyes with acute endophthalmitis. Methods: We included 226 eyes with acute endophthalmitis, treated using a standardized protocol. Visual outcome up to 12 months was assessed related to biopsy results, antibiotics resistance and treatment regimens.
View Article and Find Full Text PDFPurpose: Comparison of sarcoid uveitis with other non-infectious uveitis treatment and visual outcomes.
Methods: Retrospective study of 287 eyes with sarcoid uveitis and 1517 eyes with other non-infectious uveitis (15,029 eye-years follow-up).
Results: Sarcoid uveitis patients presented at age 43.
Prospective study of morphologic and functional parameter changes post intravitreal therapy for macular edema.
Graefes Arch Clin Exp Ophthalmol
September 2020
Purpose: Retinal sensitivity (RS) can be a valuable indicator of retinal function in response to intravitreal steroid or anti-VEGF treatment in the eyes with diabetic macular edema (DME), macular edema post retinal vein occlusion (RVO), or uveitis.
Methods: This prospective longitudinal study included 68 patients (96 eyes) with macular edema (ME) secondary to diabetes mellitus (42 eyes), uveitis (36 eyes), or RVO (18 eyes). In addition to best corrected visual acuity (BCVA) and retinal thickness, Nidek MP1 microperimetry was used to quantify RS at baseline visit and to look at the mean difference (MD) at 3-6 months and 1-2 years post intravitreal therapy with corticosteroids or anti-VEGF.
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of 1% rimexolone ophthalmic suspension in treating chronic anterior uveitis in children at a specialized medical center.
- A total of 24 patients were analyzed over 12 months, revealing significant reductions in the need for oral steroids and the frequency of uveitis flare-ups, along with stable intraocular pressure (IOP) levels.
- The findings indicate that rimexolone is a reliable topical steroid option for managing pediatric anterior uveitis without adversely affecting vision or increasing medication needs.
Purpose: To develop a robust approach to clinical phenotyping of multifocal choroiditis (MFC) and punctate inner choroidopathy (PIC).
Design: Cross-sectional and longitudinal observational study.
Methods: This multicenter study included sites in the United Kingdom and Israel.
Purpose: To examine a large cohort of patients treated with biologic agents for active noninfectious intermediate uveitis, posterior uveitis, or panuveitis (NIPPU) and to compare their efficacy and long-term effect.
Design: Retrospective, longitudinal study.
Participants: Eighty-two patients (156 eyes) with active NIPPU after failure of treatment with corticosteroids and a second-line immunosuppression drug and treated with biologic agents who were treated at Moorfields Eye Hospital between 2001 and 2016.
Importance: Cataract is one of the most common complications associated with uveitis, and is the leading cause of vision loss in these patients.
Background: The study aimed to evaluate the effect of phacoemulsification on the long-term clinical outcome and inflammation control in uveitis patients.
Design: Longitudinal study.
Purpose: To determine factors affecting the visual outcome in eyes with retinal vasculitis and the rate of neovascularization relapse in ischemic vasculitis.
Design: Retrospective cohort study.
Methods: We reviewed 1169 uveitis patients from Moorfields Eye Hospital, London, UK.
Purpose: To determine the risk factors for the development of cataract in children with uveitis of any etiology.
Design: Cohort study.
Methods: Two hundred forty-seven eyes of 140 children with uveitis were evaluated for the development of vision-affecting cataract.
Purpose: To describe factors that predict visual loss and complications in intermediate uveitis.
Design: Cross-sectional study.
Participants: Subjects with intermediate uveitis were identified from a database of 1254 uveitis patients seen in the clinic of a single consultant (S.