Cost minimization analysis of a hexavalent vaccine in Argentina.

Background: Argentina currently uses a pentavalent vaccine containing diphtheria, tetanus, pertussis (whole cell), Haemophilus influenza type b and hepatitis B antigens, administered concomitantly with the inactivated polio vaccine (IPV) (DTwP-Hib-HB plus IPV) in its childhood vaccination schedule. However, hexavalent vaccines containing acellular pertussis antigens (DTaP-Hib-HB-IPV) and providing protection against the same diseases are also licensed, but are only available with a private prescription or for high-risk pre-term infants in the public health program. We analyzed the cost of switching from the current schedule to the alternative schedule with the hexavalent vaccine in Argentina, assuming similar levels of effectiveness.

Physical, chemical, sorption and microbiological characteristics of fennel fruits.

Fennel ( Mill. var. Mill) is an annual aromatic plant of the Lamiaceae family.

Inhibition of nitric oxide synthase or cystathionine gamma-lyase abolishes leptin-induced fever in male rats.

Leptin is an adipokine that regulates energy balance and immune function. Peripheral leptin administration elicits prostaglandin E₂-dependent fever in rats. The gasotransmitters nitric oxide (NO) and hydrogen sulfide (H₂S) are also involved in lipopolysaccharide (LPS)-induced fever response.

Switching from trivalent to quadrivalent inactivated influenza vaccines in Uruguay: a cost-effectiveness analysis.

We evaluated the cost-utility of replacing trivalent influenza vaccine (TIV) with quadrivalent influenza vaccine (QIV) in the current target populations in Uruguay. An existing decision-analytic static cost-effectiveness model was adapted for Uruguay. The population was stratified into age groups.

Valuing the cost of improving Chilean primary vaccination: a cost minimization analysis of a hexavalent vaccine.

Background: The phased withdrawal of oral polio vaccine (OPV) and the introduction of inactivated poliovirus vaccine (IPV) is central to the polio 'end-game' strategy.

Methods: We analyzed the cost implications in Chile of a switch from the vaccination scheme consisting of a pentavalent vaccine with whole-cell pertussis component (wP) plus IPV/OPV vaccines to a scheme with a hexavalent vaccine with acellular pertussis component (aP) and IPV (Hexaxim®) from a societal perspective. Cost data were collected from a variety of sources including national estimates and previous vaccine studies.

[Effective tocolysis without β-agonists].

Unlabelled: Many years the β-mimetics (Partussisten, Gynipral) were first line tocolytic agents in terms of delaying premature delivery in our country. As these medicaments have been withdrawn from the pharmacy network, some concerns began to appear among our colleges considering the administration of other tocolytics and their effectiveness. Our goal is to compare the efficacy of other tocolytics with β-mimetics.

[Impact of the ammount of medicaments, administered as adjuvant chemotherapy, over the survival of female patients with early epitelial ovarian cancer].

Unlabelled: A cohort of 215 female patients with early epithelial ovarian cancer, researched for 13 year period (2000-2012). The authors are setting a goal to investigate how does the amount of chemotherapeutic medicaments, administered as adjuvant therapy influences the survival of these patients.

Conclusion: The application of three or more chemotherapeutic agents does not improve the survival of female patients with early epithelial ovarian cancer, indicated for chemotherapy.

[Tumor size and prognosis for patients with epithelial ovarian carcinoma at early stage].

Unlabelled: The goal of the research is to discover and analyze the dependence of survival on the tumor size in a cohort of 215 female patients with early epithelial ovarian cancer fallowed up for 13 year period (2000-2012). After multiple analyze among 18 other prognostic factors, using Cox proportional regression, tumor size remained one of five most significant.

Conclusion: The bigger the size of the tumor, the poorer the prognosis for the overall survival (p = 0.

[Laparoscopy and early ovarian cancer].

Unlabelled: Review of modern opinions and tendencies, concerning the role of laparoscopic surgery for the staging and treatment of ovarian cancer stage I-II.

Conclusion: The laparoscopic approach of surgical staging of early ovarian cancer is equal and even has more advantages then conventional laparotomy if it is performed from gynecologists- oncologists with enough skills and experience in laparoscopic surgery.

[Operative treatment--prognostic factor in patients with ovarian cancer stage I-II].

Objective: The authors present and analyze the modern concepts of the role of surgery as a prognostic factor for patients with early epithelial ovarian cancer (st. I-II). They review, synthetize and summarize the information from 15 studies, published in the recent years, and concerning the subject.

[The role of adjuvant chemotherapy as a prognostic factor in patients with early stage of epithelian ovarian cancer (I - II stage)].

Unlabelled: The authors present and analyze the modem concepts of the role of adjuvant chemotherapy as a prognostic factor for patients with early epithelial ovarian cancer (st. I-II). They review, synthetize and summarize the information from studies and researches, published in the recent years, and concerning the subject.

[Postoperatively conformed effectiveness of preoperative radio therapy, combined with chemotherapy - cysplatin].

The authors present a case of a 35 years old female patient with spinocellular carcinoma of the cervix, diagnosed after byopsy and treated with radiotherapy 30 Gray, combined with Cisplatin 50 mg. per square meter, per week, 6 months before radical histerectomy and lymphonodulectomy was performed. The postoperative histology shows only traces of dysplastic epithelia, which proves preoperative therapy effective.

[Angioleiomyoma utery in a female patient with damaged health condition. Diagnostic and terapeutic difficulties].

35 years old patient with many health problems, on a haemodialysis and a big abdominal tumor originating from the pelvis. The authors share their clinical approach and their diagnostic and terapeutic difficulties in this case and refer to one of their previous publications.

[Female with severe multiorgan damage and algetic myoma utery].

Painfull myoma utery in a patient with poor health condition and many disfunctional organs: Diabetes mellitus, Chronic renal insufficiency Gr. III (most probably a result of compression of the ureters causing bilateral hydronephrosis), arterial hypertony, anemia. The authors introduce their therapeutic model and manage to perform successfull operation after stabilizing the patient and intensive postoperative care.

[Endometrial cancer, turned out to be an endometroid ovarian cancer stage II].

43 years old female patients endometrial biopsy diagnosis shows highly differentiated adenocarcinoma. Because of this result she underwent total hysterectomy two weeks later, and the new hystology result is: highly differentiated endometroid ovarian carcinoma.

[Operative method of cervix conisation].

The authors describe an operative method of cervix conisation, which they used by 41 patients in a 11-years period (1998-2009). Shearing their experience of the results they achieved, they are making some conclusions.

[Rare form of cervix carcinoma, infiltrating cervical myoma].

The authors describe rare case of carcinoma colli uteri, which grows to infiltrate submucose cervical myoma.

Effects of castration-induced visceral obesity and antioxidant treatment on lipid profile and insulin sensitivity in New Zealand white rabbits.

Molecular mechanisms, responsible for the impaired insulin-sensitivity state due to the obesity are not fully understood in both humans and animals. The purpose of this study was to investigate the effects of castration-induced visceral obesity and the influence of two antioxidants on constituents of blood lipid profile and insulin sensitivity in New Zealand white rabbits. Twenty-six clinically healthy male New Zealand white rabbits were used in the experiment and were divided into 3 groups: first group (CI, n=7) - castrated-obese and treated with antioxidants "Immunoprotect" for 2months; second group (CO, n=7) - castrated-obese; third group (NC, n=12) - control group (non-castrated, non-obese).

[A case of a papilloferous cystadenoma of boundary malignancy in a 29-year-old female patient with high surgical risk].

A case of papilloferous serous cystadenoma of boundary malignancy in a 29-year old female patient, with VCS syndrome--status post phlebothrombosis ileofemoralis dextra. Thrombosis vena cava superior is presented.

[Is the breech presentation and delivery normal or pathological?].

The authors share their opinion, comparing their personal experience with the data in the world literature.

[Rate of cesarean section with breech presentation in Stara Zagora for 12-years period].

The authors review and analyse the structure and the rate of the cesarean section with breech presentation in Stara Zagora, Bulgaria, for 12-years period. They present their algorithm of work.

[Fetal mortality of children in breech presentation for the period 1990-2001 (12 years)].

The authors review 12-years period (1990-2001) during which they research the fetal mortality of children born in breech presentation in the University clinic of Obstetrics and Gynecology of Stara Zagora, Bulgaria. They present a figure of the possible risks for the fetus in breech presentation and breech delivery.

[Prematurity, breech presentation, and delivery].

The authors research 248 immature infants (> 1000 < 2500 g), born in breech presentation in the Clinic of Obstetrics and Gynecology, Stara Zagora in 12 years (1990-2001).

[Choice of the type of manual assistance used during delivery of a fetus in breech presentation].

The authors show statistics of the manual assistance methods, performed by the obstetricians in the clinic of obstetrics and gynecology of Stara Zagora, when delivering of fetuses in breach presentation. They observe 12-year period and introduce their algorithm.

[Multiple pregnancy and breech presentation].

The article is about multiple pregnancy with twins during labor, when the first twin is in vertex presentation and the second is in breech presentation. The authors observe the obstetrical management in this combination in the clinic of Obstetrics and Gynecology in Stara Zagora for 12 years period--1990-2001.