Assessing vocabulary acquisition using a fast-mapping task in an Android application: A pilot study.

Purpose: The aim of this study was to explore whether a fast mapping task embedded in an Android application (FastMApp) is a valid tool to assess referent selection abilities in Spanish-speaking children aged between 18 and 30 months. Traditional assessment tools for lexical development use static quantitative methods that assign children a final score to represent their overall vocabulary level. These methods fail to provide insights into the learning process, despite their potential relevance for clinical and educational purposes.

Emergent biaxiality in chiral hybrid liquid crystals.

Biaxial nematic liquid crystals are fascinating systems sometimes referred to as the Higgs boson of soft matter because of experimental observation challenges. Here we describe unexpected states of matter that feature biaxial orientational order of colloidal supercritical fluids and gases formed by sparse rodlike particles. Colloidal rods with perpendicular surface boundary conditions exhibit a strong biaxial symmetry breaking when doped into conventional chiral nematic fluids.

Neuromodulation with Transcranial Magnetic Stimulation in Epilepsia Partialis Continua: Scoping review and clinical experience.

Introduction: Epilepsia Partialis Continua (EPC) is a challenging condition in which repetitive transcranial magnetic stimulation (rTMS) can induce a neuromodulation effect of potential diagnostic and therapeutic value.

Methods: A comprehensive literature search was conducted using Pubmed and Web of Science databases to identify cases of EPC who underwent rTMS, including children and adults. Additionally, we present two patients from our centre who underwent rTMS at a low frequency (0.

Validation of electronic health record data to identify hospital-associated infections for retrospective research.

infection (CDI) research relies upon accurate identification of cases when using electronic health record (EHR) data. We developed and validated a multi-component algorithm to identify hospital-associated CDI using EHR data and determined that the tandem of CDI-specific treatment and laboratory testing has 97% accuracy in identifying HA-CDI cases.

Retrospective study assessing the role of the androgen receptor in clear cell renal cell cancer patients treated with VEGFR inhibitors in monotherapy.

Background And Purpose: Despite that incorporating antiangiogenic in combination with immune-checkpoint inhibitors as the standard first-line treatment for advanced clear cell renal cell cancer (ccRCC) yields promising outcomes, these regimens often lead to significant toxicity. However, a subgroup of patients has shown responsiveness to VEGFR tyrosine-kinase inhibitors (TKIs) in monotherapy, leading to the question of whether employing combination therapies can significantly enhance overall survival in all patients over monotherapy. Thus, we aim to identify gene expression signatures that can predict TKI response within subpopulations that might benefit from single-agent therapies, to minimize unnecessary exposure to combination therapies and their associated toxicities, as well as to discover new potential therapeutic targets to improve ccRCC treatment.

Reproductive and pregnancy control in Wilson disease patients in Spain.

Background And Aim: Recommendations on pregnancy, lactation, and contraception in women with Wilson disease are briefly stated in international guidelines but are not entirely homogeneous. Data regarding the management of these special events among patients with Wilson disease in Spain are lacking. We used the Wilson Registry platform of the Spanish Association for the Study of the Liver to question patients on their reproductive and gestational lives.

Directing novel ChoKα1 inhibitors using MamC-mediated biomimetic magnetic nanoparticles: a way to improve specificity and efficiency.

Targeting phospholipid biosynthesis, specifically phosphatidylcholine (PC), which is enhanced in tumor cells, has been proven a suitable antitumor strategy. In fact, the overexpression of the choline kinase α1 (ChoKα1) isoform has been found in malignant cells and tumors, thus becoming an excellent antitumor target. ChoKα1 inhibitors are being synthesized at the present that show a large inhibitory activity.

Mind the suffix: Pseudoword processing in children and adults.

Previous evidence has shown that pseudowords made up of real morphemes take more time to process and generate more errors than pseudowords without morphemes in a lexical decision task. The explanation for these results is controversial because two possible arguments may be posited; the first is related to the morphological composition of the stimuli, and the second is related to the larger semantic interpretability of pseudowords with morphemes in comparison with pseudowords without morphemes (a semantic-based explanation). To disentangle this issue, we conducted an experiment with 92 children and 42 adults.

Outcomes and patterns of use of Radium-223 in metastatic castration-resistant prostate cancer.

Introduction: Radium-223 dichloride (Ra-223) is recommended as a treatment option for metastatic castration-resistant prostate cancer (mCRPC) patients with symptomatic bone metastases and no visceral disease, after docetaxel failure, or in patients who are not candidates to receive it. In this study, we aimed to ambispectively analyze overall survival (OS) and prognostic features in mCRPC in patients receiving Ra-223 as per clinical routine practice and identify the most suitable treatment sequence.

Patients And Methods: This study is observational, multicentric, and ambispective.

Transposition and substitution-letter effects in a flanker task: Evidence from children and adults.

Several studies have shown that parafoveal processing is essential in reading development. In this study, we explore the effect of transposing and substituting inner and outer letters in a flanker lexical decision task administered to 78 children and 65 adults. The results show a significant interaction between the Group factor and the Flanker factor, suggesting differences in the effects of flankers for children and adults.

Comparison of the Influence of Oxygen Groups Introduced by Graphene Oxide on the Activity of Carbon Felt in Vanadium and Anthraquinone Flow Batteries.

An increasing number of studies focus on organic flow batteries (OFBs) as possible substitutes for the vanadium flow battery (VFB), featuring anthraquinone derivatives, such as anthraquinone-2,7-disulfonic acid (2,7-AQDS). VFBs have been postulated as a promising energy storage technology. However, the fluctuating cost of vanadium minerals and risky supply chains have hampered their implementation, while OFBs could be prepared from renewable raw materials.

One-step Bayesian example-dependent cost classification: The OsC-MLP method.

Example-dependent cost classification problems are those where the decision costs depend not only on the true and the attributed classes but also on the sample features. Discriminative algorithms that carry out such classification tasks must take this dependence into account. In some applications, the decision costs are known for the training set but not in production, which complicates the problem.

"I don't know who you are": anomia for people's names in Alzheimer's disease.

It is well known that difficulty in the retrieval of people's names is an early symptom of Alzheimer's Disease Dementia (ADD), but there is a controversy about the nature of this deficit. In this study, we analyzed whether the nature of the difficulty in retrieving proper names in ADD reflects pre-semantic, semantic, or post-semantic difficulties. To do so, 85 older adults, 35 with ADD and 50 cognitively healthy (CH), completed a task with famous faces involving: recognition, naming, semantic questions, and naming with phonological cues.

Use of electronic health record data to identify hospital-associated infections: a validation study.

Background: Clinical research focused on the burden and impact of infection (CDI) often relies upon accurate identification of cases using existing health record data. Use of diagnosis codes alone can lead to misclassification of cases. Our goal was to develop and validate a multi-component algorithm to identify hospital-associated CDI (HA-CDI) cases using electronic health record (EHR) data.

Tailored Porous Carbon Xerogels for Fe-N-C Catalysts in Proton Exchange Membrane Fuel Cells.

Atomically dispersed Fe-N-C catalysts for the oxygen reduction reaction (ORR) have been synthesized with a template-free method using carbon xerogels (CXG) as a porous matrix. The porosity of the CXGs is easily tunable through slight variations in the synthesis procedure. In this work, CXGs are prepared by formaldehyde and resorcinol polymerization, modifying the pH during the process.

The importance of cell uptake in photothermal treatments mediated by biomimetic magnetic nanoparticles.

Biomimetic magnetic nanoparticles (BMNPs) mediated by MamC have proven to be photothermal agents able to allow an optimized cytotoxicity against tumoral cells when used simultaneously as drug nanotransporters and as hyperthermia agents. However, it remains unclear whether BMNPs need to be internalized by the cells and/or if there is a threshold for internal Fe concentration for the photothermal therapy to be effective. In this study, three different situations for photothermal treatments have been simulated to disentangle the effect of BMNPs cell uptake on cell viability after photothermal treatments.

Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation.

Among transmissible spongiform encephalopathies or prion diseases affecting humans, sporadic forms such as sporadic Creutzfeldt-Jakob disease are the vast majority. Unlike genetic or acquired forms of the disease, these idiopathic forms occur seemingly due to a random event of spontaneous misfolding of the cellular PrP (PrP) into the pathogenic isoform (PrP). Currently, the molecular mechanisms that trigger and drive this event, which occurs in approximately one individual per million each year, remain completely unknown.

[The effect of the pandemic on language development in the first two years of life].

Background And Objectives: The effects that the COVID-19 pandemic may have had on the language development of children are still poorly understood. In this study, we examine the effect of the pandemic on this development by analyzing the vocabulary and the morphosyntactic level in a sample of toddlers.

Participants And Method: One hundred and fifty-three boys and girls between 18 and 31 months of age participated in the study.

Carbonized Polydopamine-Based Nanocomposites: The Effect of Transition Metals on the Oxygen Electrocatalytic Activity.

The electrochemical oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are the most critical processes in renewable energy-related technologies, such as fuel cells, water electrolyzers, and unitized regenerative fuel cells. N-doped carbon composites have been demonstrated to be promising ORR/OER catalyst candidates because of their excellent electrical properties, tunable pore structure, and environmental compatibility. In this study, we prepared porous N-doped carbon nanocomposites (NC) by combining mussel-inspired polydopamine (PDA) chemistry and transition metals using a solvothermal carbonization strategy.

Smart Spread Spectrum Modulated Tags for Detection of Vulnerable Road Users with Automotive Radar.

In recent years, there has been a significant increase in the number of collisions between vehicles and vulnerable road users such as pedestrians, cyclists, road workers and more recently scooter riders, especially in urban streets. This work studies the feasibility of enhancing the detection of these users by means of CW radars because they have a low radar cross section. Since the speed of these users is usually low, they can be confused with clutter due to the presence of large objects.

Correction: Personalized Precision Medicine for Health Care Professionals: Development of a Competency Framework.

[This corrects the article DOI: 10.2196/43656.].