A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization.

Tools for acute manipulation of protein localization enable elucidation of spatiotemporally defined functions, but their reliance on exogenous triggers can interfere with cell physiology. This limitation is particularly apparent for studying mitosis, whose highly choreographed events are sensitive to perturbations. Here we exploit the serendipitous discovery of a phosphorylation-controlled, cell cycle-dependent localization change of the adaptor protein PLEKHA5 to develop a system for mitosis-specific protein recruitment to the plasma membrane that requires no exogenous stimulus.

Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with and mild cognitive impairment.

Introduction: At least one-third of the identified risk alleles from Genome-Wide Association Studies (GWAS) of Alzheimer's disease (AD) are involved in lipid metabolism, lipid transport, or direct lipid binding. In fact, a common genetic variant (ε4) in a cholesterol and phospholipid transporter, Apolipoprotein E (), is the primary genetic risk factor for late-onset AD. In addition to genetic variants, lipidomic studies have reported severe metabolic dysregulation in human autopsy brain tissue, cerebrospinal fluid, blood, and multiple mouse models of AD.

A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization.

Tools for acute manipulation of protein localization enable elucidation of spatiotemporally defined functions, but their reliance on exogenous triggers can interfere with cell physiology. This limitation is particularly apparent for studying mitosis, whose highly choreographed events are sensitive to perturbations. Here we exploit the serendipitous discovery of a phosphorylation-controlled, cell cycle-dependent localization change of the adaptor protein PLEKHA5 to develop a system for mitosis-specific protein recruitment to the plasma membrane that requires no exogenous stimulus.

Synchrotron intensity gradient revealing magnetic fields in galaxy clusters.

Magnetic fields and their dynamical interplay with matter in galaxy clusters contribute to the physical properties and evolution of the intracluster medium. However, the current understanding of the origin and properties of cluster magnetic fields is still limited by observational challenges. In this article, we map the magnetic fields at hundreds-kpc scales of five clusters RXC J1314.

Nanoparticles Surface Chemistry Influence on Protein Corona Composition and Inflammatory Responses.

Nanoparticles are widely used for biomedical applications such as vaccine, drug delivery, diagnostics, and therapeutics. This study aims to reveal the influence of nanoparticle surface functionalization on protein corona formation from blood serum and plasma and the subsequent effects on the innate immune cellular responses. To achieve this goal, the surface chemistry of silica nanoparticles of 20 nm diameter was tailored via plasma polymerization with amine, carboxylic acid, oxazolines, and alkane functionalities.

Mechanistic investigation of thermosensitive liposome immunogenicity and understanding the drivers for circulation half-life: A polyethylene glycol versus 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol study.

Various thermosensitive liposome (TSL) formulations have been described to date and it is currently unclear which are optimal for solid tumor treatment. Sufficient circulation half-life is important and most liposomes obtain this by polyethylene glycol (PEG) surface modification. 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol (DPPG) has been described as a promising alternative which increases TSL circulation half-life and facilitates rapid drug release under mild hyperthermia at 20-30 mol%.

Inertial-Range Reconnection in Magnetohydrodynamic Turbulence and in the Solar Wind.

In situ spacecraft data on the solar wind show events identified as magnetic reconnection with wide outflows and extended "X lines," 10(3)-10(4) times ion scales. To understand the role of turbulence at these scales, we make a case study of an inertial-range reconnection event in a magnetohydrodynamic simulation. We observe stochastic wandering of field lines in space, breakdown of standard magnetic flux freezing due to Richardson dispersion, and a broadened reconnection zone containing many current sheets.

Turbulent reconnection and its implications.

Magnetic reconnection is a process of magnetic field topology change, which is one of the most fundamental processes happening in magnetized plasmas. In most astrophysical environments, the Reynolds numbers corresponding to plasma flows are large and therefore the transition to turbulence is inevitable. This turbulence, which can be pre-existing or driven by magnetic reconnection itself, must be taken into account for any theory of magnetic reconnection that attempts to describe the process in the aforementioned environments.

Particle acceleration in turbulence and weakly stochastic reconnection.

In this Letter we analyze the energy distribution evolution of test particles injected in three dimensional (3D) magnetohydrodynamic (MHD) simulations of different magnetic reconnection configurations. When considering a single Sweet-Parker topology, the particles accelerate predominantly through a first-order Fermi process, as predicted in and demonstrated numerically in . When turbulence is included within the current sheet, the acceleration rate is highly enhanced, because reconnection becomes fast and independent of resistivity and allows the formation of a thick volume filled with multiple simultaneously reconnecting magnetic fluxes.

Low-Mach-number turbulence in interstellar gas revealed by radio polarization gradients.

The interstellar medium of the Milky Way is multiphase, magnetized and turbulent. Turbulence in the interstellar medium produces a global cascade of random gas motions, spanning scales ranging from 100 parsecs to 1,000 kilometres (ref. 4).

Scattering of cosmic rays by magnetohydrodynamic interstellar turbulence.

Recent advances in understanding of magnetohydrodynamic (MHD) turbulence call for substantial revisions in our understanding of cosmic ray transport. We use recently obtained scalings of MHD modes to calculate the scattering frequency for cosmic rays. We consider gyroresonance with MHD modes (Alfvénic, slow, and fast) and transit-time damping by fast modes.

Compressible sub-Alfvénic MHD turbulence in low-beta plasmas.

We present a model for compressible sub-Alfvénic isothermal magnetohydrodynamic (MHD) turbulence in low- beta plasmas and numerically test it. We separate MHD fluctuations into three distinct families: Alfvén, slow, and fast modes. We find that production of slow and fast modes by Alfvénic turbulence is suppressed.

Ultra-High-Energy Cosmic-Ray Acceleration by Magnetic Reconnection in Newborn Accretion-induced Collapse Pulsars.

We here investigate the possibility that the ultra-high-energy cosmic-ray (UHECR) events observed above the Greisen-Zatsepin-Kuzmin (GZK) limit are mostly protons accelerated in reconnection sites just above the magnetosphere of newborn millisecond pulsars that are originated by accretion-induced collapse (AIC). We formulate the requirements for the acceleration mechanism and show that AIC pulsars with surface magnetic fields 1012 G/=10(20) eV. Because the expected rate of AIC sources in our Galaxy is very small ( approximately 10(-5) yr(-1)), the corresponding contribution to the flux of UHECRs is negligible and the total flux is given by the integrated contribution from AIC sources produced by the distribution of galaxies located within the distance that is unaffected by the GZK cutoff ( approximately 50 Mpc).

Resonance Paramagnetic Relaxation and Alignment of Small Grains.

We show that the energy-level splitting that arises from grain rotation ensures that paramagnetic dissipation acts at its maximum rate, i.e., the conditions for paramagnetic resonance are automatically fulfilled.