Publications by authors named "Lazareva M"

Background: The emergence of a new coronavirus strain caused the COVID-19 pandemic. While vaccines effectively control the infection, it's important to acknowledge the potential for side effects, including rare cases like psychosis, which may increase with the rising number of vaccinations.

Objectives: Our systematic review aimed to examine cases of new-onset psychosis following COVID-19 vaccination.

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Background: We aimed to describe bacterial etiology of acute otitis media (AOM) and characterize resistance, serotypes and genotype profiles of AOM-causing pneumococci recovered in Moscow children.

Methods: Children with AOM and an available middle ear fluid specimen were prospectively enrolled in this study. Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis were considered as true otopathogens.

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Data on the selectivity of the Lewis acids induced transformations of the title compounds are presented, and the routes leading to formation of products containing either cyclohexane or 1,3-diene units are described.

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Mental performance and adaptation to exercise and psychoemotional loads were studied in 119 patients with neurocirculatory asthenia (NCA), 245 patients with chronic focal infection (CFI) of the upper airways, and 247 NCA patients with CFI. Exercise tolerance was measured at spiroergometry, intellectual and psychoemotional adaptation were assessed by shifts in attention and fatigue while working with Schulte tables under conditions of time limits and the results criticism, vegetative reactivity was tested with insulin and epinephrine, variation pulsograms recorded vegetative provision of physical, intellectual and psychoemotional activity. Abnormalities in mental performance and the above adaptation related to clinical presentation of NCA and CFI as well as to vegetative regulation were registered in NCA+CFI patients.

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The A6 antigen--a surface-exposed component shared by mouse oval and biliary epithelial cells--was examined during prenatal development of mouse in order to elucidate its relation to liver progenitor cells. Immunohistochemical demonstration of the antigen was performed at the light and electron microscopy level beginning from the 9.5 day of gestation (26-28 somite pairs).

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Monoclonal antibodies (MAb) were produced against antigens (Ag) of oval cells isolated from the preneoplastic murine liver. To suppress the immune response to major antigens common with hepatocytes, the principle of anti-idiotype immunization was employed. Characteristics of three MAb reacting selectively with the foci of oval cell proliferation are described.

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Gas chromatographic procedure was used for quantitative estimation of metabolic [volatile fatty acids (C2-C6)] of anaerobic bacteria in express diagnosis of nonclostridial anaerobic infection in surgical patients with purulent bacterial destruction of lungs and with abdominal impairments as well as in patients with calculous cholecystitis. Only traces of acid metabolites were detected in donor blood. A 10-30-fold increase in their content in blood of patients with surgical and gynecologic sepsis enabled to diagnose the anaerobic form of the disease.

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Seventy eight patients with bacterial destruction of the lungs were under observation. Non-clostridial anaerobic microflora was identified by a method of gas-liquid chromatography in 57(74.6%) patients.

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Results of examination and treatment of 194 patients with acute complicated abscesses of the lungs were analyzed. The main pathogenic agent of this pathology is gram-negative microorganisms and anaerobic neclostridial flora. Methods of bacterioscopy and gas-liquid chromatography were used for its verification.

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The AFP-synthesizing cells were identified by ultrastructural localization of the antigen in regenerating liver of adult mice after CCl4 poisoning. An indirect immunoperoxidase method with rabbit anti-mouse AFP and peroxidase conjugates of anti-rabbit IgG or their Fab' was used. Good preservation of AFP and tissue structure, and sufficient permeability for the conjugates were obtained after 20' prefixation of small liver specimens in 8% formaldehyde -0.

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Ultrastructural localization of alpha-fetoprotein (AFP) was studied with the use of the indirect immunoperoxidase technique in the regenerating liver of three strains of mice after CCl4 poisoning. Upon the use of monoclonal and monospecific antibodies AFP synthesis was revealed in part of mature hepatocytes and in smaller cells. No analogues of small cells were found in the normal liver.

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DNA synthesis in the regenerating liver of mice poisoned with carbon tetrachloride (CCl4) was inhibited by infusion of hydroxyurea (HU). The infusion was started prior to the beginning of DNA synthesis and continued up to 60-72 h after CCl4 administration. The AFP-containing cells in liver were demonstrated by the immunoperoxidase technique.

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Induction of the synthesis of the embryo-specific protein--alpha-fetoprotein (alpha-FP) was revealed in the SWR mice of different age after one or several CCl4 treatments. The alpha-FP level elevation was the greatest in mice aged under one month. Morphologically in the liver regenerating after CCl4 poisoning the alpha-FP-containing hepatocytes failed to differ from the principal mass of cells, i.

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Typical mature hepatocytes constituting not over several per cent of the total amount of preserved hepatocytes served as the principal site of the alpha-fetoprotein (AFP) localization in the liver of mice regenerating after the CCl4 poisoning or partial hepatectomy. Morphologically they failed to differ from the principal mass of hepatocytes and retained an antigen of the bile capillaries on the surface. A change id to the dynamics of the AFP level in the animal serum.

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A combination of gel permeation chromatography (GPC), thin-layer chromatography (TLC) and pyrolysis gas chromatography (PGC) has been used for investigations of a polymethyl methacrylate-polystyrene-polymethyl methacrylate block copolymer. Continuous distribution of the polymer (40-mg sample) was attained according to the content of the styrene and methyl methacrylate units and of the block copolymer and according to the composition of the copolymer as functions of the hydrodynamic radius of the macromolecules. The polymer was subjected to a preliminary fractionation with an analytical gel chromatograph.

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