Longitudinal T cell repertoire analysis reveals dynamic clonal T cell populations in Ulcerative Colitis.

Background: Ulcerative Colitis (UC) is characterized by chronic, relapsing and remitting inflammation in the colon and rectum. Pathogenic T cell activity is thought to play a major role in this process. T cell effector function is determined by the T cell receptor (TCR) and the antigen it recognizes.

[Diagnostic capabilities of sound-breathing test in assessment of pulmonary ventilation function in children and adults (retrospective review and prospect)].

Objective: To develop and try out a convenient and accessible for use technology for testing the pulmonary function in children and adults, including in patients with chronic bronchopulmonary pathology.

Material And Methods: The article presents the results of Lazarev sound-breathing test (LST) in different cohorts of children and adults, including pregnant women and children suffering from chronic bronchopulmonary diseases, in particular cystic fibrosis.

Results: A direct dependence of the LST indicators' level from the age of children and adolescents has been obtained.

Clinical Course of Isolated Recurrent, Persistent Complex Perianal Fistulas Without Luminal Crohn's Disease: A Multicenter Case Series of 24 Patients.

Background: Isolated complex perianal fistulas, without luminal evidence of inflammatory bowel disease in the gastrointestinal tract, pose diagnostic and treatment dilemmas for gastroenterologists and colorectal surgeons. For patients who develop recurrent complex fistulas, a presumptive diagnosis of Crohn's disease may be made. It is unclear whether these cases of isolated perianal disease in the absence of luminal inflammation truly represent isolated severe cryptoglandular fistulas or rather an early presentation of Crohn's disease.

AI in interventional cardiology: Innovations and challenges.

Artificial Intelligence (AI) permeates all areas of our lives. Even now, we all use AI algorithms in our daily activities, and medicine is no exception. The potential of AI technology is hard to overestimate; AI has already proven its effectiveness in many fields of science and technology.

A Concept of Local Coordination Number for the Characterization of Solute Clusters within Atom Probe Tomography Data.

Identifying clusters of solute atoms in a matrix of solvent atoms helps to understand precipitation phenomena in alloys, for example, during the age hardening of certain aluminum alloys. Atom probe tomography datasets can deliver such information, provided that appropriate cluster identification routines are available. We investigate algorithms based on the local composition of the neighborhood of solute atoms and compare them with traditional approaches based on the local solute number density, such as the maximum separation distance method.

Aberrant N-glycosylation is a therapeutic target in carriers of a common and highly pleiotropic mutation in the manganese transporter ZIP8.

The treatment of defective glycosylation in clinical practice has been limited to patients with rare and severe phenotypes associated with congenital disorders of glycosylation (CDG). Carried by approximately 5% of the human population, the discovery of the highly pleiotropic, missense mutation in a manganese transporter ZIP8 has exposed under-appreciated roles for Mn homeostasis and aberrant Mn-dependent glycosyltransferases activity leading to defective N-glycosylation in complex human diseases. Here, we test the hypothesis that aberrant N-glycosylation contributes to disease pathogenesis of ZIP8 A391T-associated Crohn's disease.

After Surgically Induced Remission, Ileal and Colonic Mucosa-Associated Microbiota Predicts Crohn's Disease Recurrence.

Background & Aims: Investigating the tissue-associated microbiota after surgically induced remission may help to understand the mechanisms initiating intestinal inflammation in Crohn's disease.

Methods: Patients with Crohn's disease undergoing ileocolic resection were prospectively recruited in 6 academic centers. Biopsy samples from the neoterminal ileum, colon, and rectosigmoid were obtained from colonoscopies performed after surgery.

Clinical Decision Making in Inflammatory Bowel Disease Mimics: Practice Management from Inflammatory Bowel Disease LIVE.

Background: Since 2009, inflammatory bowel disease (IBD) specialists have utilized "IBD LIVE," a weekly live video conference with a global audience, to discuss the multidisciplinary management of their most challenging cases. While most cases presented were confirmed IBD, a substantial number were diseases that mimic IBD. We have categorized all IBD LIVE cases and identified "IBD-mimics" with consequent clinical management implications.

[Healthy and harmonic childhood - foundation of the «Health of healthy» concept].

Within the framework of the «Health of Healthy» concept (A.N. Razumov) a medical, psychological and pedagogical «Sonatal-pedagogy» system (M.

A new species of the genus Calchaenesthes Kraatz, 1863 (Coleoptera, Cerambycidae) from Cyprus.

The new species is similar to Calchaenesthes primis zdikmen, 2013 (Figs. 3-4) described from south Anatolia (Iel province) and was often mixed with it (Ambrus, Grosser & Hrbek, 2014; zdikmen & Cihan, 2018; Danilevsky, 2020). Recently I received a good series of Calchaenesthes from Cyprus, and see several important characters, which distinguish the island population.

Clinical Predictors of Early and Late Endoscopic Recurrence Following Ileocolonic Resection in Crohn's Disease.

Background And Aims: Multiple factors are suggested to place Crohn's disease patients at risk of recurrence after ileocolic resection with conflicting associations. We aimed to identify clinical predictors of recurrence at first [early] and further [late] postoperative colonoscopy.

Methods: Crohn's disease patients undergoing ileocolic resection were prospectively recruited at six North American centres.

Antibody Kinetics after Three Doses of SARS-CoV-2 mRNA Vaccination in Patients with Inflammatory Bowel Disease.

The emergence of new SARS-CoV-2 variants calls for more data on SARS-CoV-2 mRNA vaccine response. We aimed to assess the response to a third mRNA vaccine dose against SARS-CoV-2 in inflammatory bowel disease (IBD) patients. This was a single-center, observational prospective study of IBD patients who received a third mRNA vaccine dose against SARS-CoV-2.

Prussian Blue to reduce radiocaesium accumulation in fish in lakes affected by the Chornobyl accident.

Fish in lakes situated within the Chornobyl exclusion zone have been highly contaminated since the accident and have not been utilized as food for humans. In the present study, field experiments with less-contaminated silver Prussian carp (Carassius gibelio (Bloch, 1782)) caged in contaminated lake within the Chornobyl exclusion zone was performed from June to October 2021 to investigate the effectiveness of clean feed containing potassium ferric hexacyanoferrate (KFCF) KFe[Fe(CN)], a kind of Prussian Blue as a countermeasure to reduce Cs accumulation in fish. The addition of clean feed containing 0.

Room temperature epoxidation of ethylene over delafossite-based AgNiO nanoparticles.

A mixed oxide of silver and nickel AgNiO was obtained co-precipitation in alkaline medium. This oxide demonstrates room temperature activity in the reaction of ethylene epoxidation with a high selectivity (up to 70%). Using the PDF method, it was found that the initial structure of AgNiO contains stacking faults and silver vacancies, which cause the nonstoichiometry of the oxide (Ag/Ni < 1).

Symbolic expression generation variational auto-encoder.

There are many problems in physics, biology, and other natural sciences in which symbolic regression can provide valuable insights and discover new laws of nature. Widespread deep neural networks do not provide interpretable solutions. Meanwhile, symbolic expressions give us a clear relation between observations and the target variable.

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.

Objective: Perianal Crohn's disease (pCD) occurs in up to 40% of patients with CD and is associated with poor quality of life, limited treatment responses and poorly understood aetiology. We performed a genetic association study comparing CD subjects with and without perianal disease and subsequently performed functional follow-up studies for a pCD associated SNP in ().

Design: Immunochip-based meta-analysis on 4056 pCD and 11 088 patients with CD from three independent cohorts was performed.

Artificial Intelligence Enabled Histological Prediction of Remission or Activity and Clinical Outcomes in Ulcerative Colitis.

Background & Aims: Microscopic inflammation has significant prognostic value in ulcerative colitis (UC); however, its assessment is complex with high interobserver variability. We aimed to develop and validate an artificial intelligence (AI) computer-aided diagnosis system to evaluate UC biopsies and predict prognosis.

Methods: A total of 535 digitalized biopsies (273 patients) were graded according to the PICaSSO Histologic Remission Index (PHRI), Robarts, and Nancy Histological Index.

Serum Lipidomic Screen Identifies Key Metabolites, Pathways, and Disease Classifiers in Crohn's Disease.

Background: There is an unmet medical need for biomarkers that capture host and environmental contributions in inflammatory bowel diseases (IBDs). This study aimed at testing the potential of circulating lipids as disease classifiers given their major roles in inflammation.

Methods: We applied a previously validated comprehensive high-resolution liquid chromatography-mass spectrometry-based untargeted lipidomic workflow covering 25 lipid subclasses to serum samples from 100 Crohn's disease (CD) patients and 100 matched control subjects.

Cavitary lung nodules as an extraintestinal manifestation of ulcerative colitis.

A man in his 30s with ulcerative colitis (UC) on immunosuppressive agents and extensive travel history presented with subacute dyspnoea and dry cough. CT of the chest demonstrated numerous cavitary pulmonary nodules. An extensive infectious, malignant and autoimmune evaluation was pursued, ultimately with histopathology most consistent with necrobiotic lung nodules as an extraintestinal manifestation of UC.

Constrained multiple instance learning for ulcerative colitis prediction using histological images.

Background And Objective: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) affecting the colon and the rectum characterized by a remitting-relapsing course. To detect mucosal inflammation associated with UC, histology is considered the most stringent criteria. In turn, histologic remission (HR) correlates with improved clinical outcomes and has been recently recognized as a desirable treatment target.

Advanced endoscopic resection for colorectal dysplasia in inflammatory bowel disease: a meta-analysis.

Little is known about outcomes of advanced endoscopic resection (ER) for patients with inflammatory bowel disease (IBD) with dysplasia. The aim of our meta-analysis was to estimate the safety and efficacy of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for dysplastic lesions in patients with IBD. We performed a systematic review through Jan 2021 to identify studies of IBD with dysplasia that was treated by EMR or ESD.

Endoscopic submucosal dissection for colorectal dysplasia in inflammatory bowel disease: a US multicenter study.

In patients with inflammatory bowel disease (IBD), endoscopically visible lesions with distinct borders can be considered for endoscopic resection. The role of endoscopic submucosal dissection (ESD) for these lesions is not well defined because of a paucity of data. We aimed to evaluate the outcomes of colorectal ESD of dysplastic lesions in patients with IBD across centers in the United States.