Prolonged survival and expression of neural markers by bone marrow-derived stem cells transplanted into brain lesions.

Background: Bone marrow-derived stem cell transplantation is a potentially viable therapeutic option for the treatment of neurodegenerative disease.

Material/methods: We have isolated bone marrow stem cells by standard method. We then evaluated the survival of rats' bone marrow mononuclear cells implanted in rats' brain.

Characterization of proliferation and differentiation of EGF-responsive striatal and septal precursor cells.

The epigenetic manipulation of precursors may provide data to elucidate the potential interactions among these cells in different brain regions. However, the response to epigenetic signals is modulated by the environment in which the cells are manipulated. Therefore, data regarding the action of a particular factor must be considered in the light of a specific system.