Publications by authors named "Lazar J"

Objective: With robotic technology's rapid growth and integration, an urgent need to bridge the educational gap in thoracic surgical training has emerged. This document, a result of consensus among a group of experts in the practice and training of robotic surgery from the Society of Thoracic Surgeons (STS), aims to provide a framework for a standardized national robotic curriculum for thoracic surgery trainees.

Methods: The STS Task Force on Robotic Thoracic Surgery and Workforce on E-learning and Educational Innovation assembled an expert group with the input of the Thoracic Surgery Director's Association (TSDA).

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Background: Heavy drinking, smoking, and depression are common among men who have sex with men (MSM). The association of co-occurring longitudinal patterns of these conditions and mortality among MSM were tested, applying a syndemic framework - the interaction of two or more conditions that contribute to poor health outcomes.

Methods: Longitudinal data from 1999 to 2018 from the Multicenter AIDS Cohort Study of 3046 MSM were analyzed.

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Article Synopsis
  • * The study introduces enhanced modeling techniques for neutrino flux and detector response, and it distinguishes between starting (inside) and throughgoing (outside) neutrino interaction events to improve energy resolution.
  • * The findings indicate a best-fit point for the 3+1 model with sin²(2θ_{24})=0.16 and Δm_{41}²=3.5 eV², supporting previous studies while showing consistency with no evidence of sterile neutrinos, as reflected
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Background: The contemporary management and resectability of locally advanced lung cancer are undergoing significant changes as new data emerge regarding immunotherapy and targeted treatments. The objective of this document is to review the literature and present consensus among a group of multidisciplinary experts to guide the determination of resectability and management of locally advanced non-small cell lung cancer (NSCLC) in the context of contemporary evidence.

Methods: The Society of Thoracic Surgeon Workforce on Thoracic Surgery assembled a multidisciplinary expert panel composed of thoracic surgeons and medical and radiation oncologists with established expertise in the management of lung cancer.

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Introduction: Student midwives exposed to effective systems of midwifery care in other countries can consider how aspects of this knowledge can translate into their healthcare system to improve maternal and infant perinatal outcomes. An optional short-term study abroad (STSA) experience was developed for US midwifery graduate students to expose them to the UK healthcare system, where midwives are considered the primary professionals for the care of the childbearing family. This qualitative study explored the influence of an STSA experience on US midwifery graduate students' learning of midwifery in the UK.

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Introduction: Detrusor muscle weakness is commonly noted on urodynamics in patients with refractory voiding difficulty. No approved therapies have been proven to augment the strength of a detrusor voiding contraction.

Methods: This subject was discussed by a think-tank at the International Consultation on Incontinence- Research Society (ICI-RS) meeting held in Bristol, June 2024.

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Objective: Asian Americans include heterogeneous subpopulations with unique burden as the only racial group with cancer as the leading cause of death. The purpose of the study was to identify differences in clinical stage and survival of patients with lung cancer between Asian Americans and its subgroups relative to other racial groups.

Methods: Patients with lung cancer from 2016 National Cancer Database were divided into East Asian, Southeast Asian, South Asian subgroups based on geographic origins, and a composite Asian American group with White non-Hispanic, Black, and Hispanic comparison groups.

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Filaroid nematodes Setaria tundra (Issaitshikoff & Rajewskaya, 1928) and Setaria cervi (Rudolphi, 1819) are internal parasites from family Onchocercidae with occurrence in the northern hemisphere. They have a considerably wide range of final host, including many species of family Cervidae. Intermediate hosts and vectors at the same time, are represented by the several mosquito species, mostly of genus Aedes.

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  • - The study presents a measurement of astrophysical tau neutrinos using 9.7 years of data from the IceCube observatory, identifying seven candidate events with energies between 20 TeV and 1 PeV.
  • - Convolutional neural networks were used to analyze simulated event images, helping to estimate the parent tau neutrino energy to be around 200 TeV while facing a background of about 0.5 events primarily from non-tau astrophysical neutrinos.
  • - The results confirmed the presence of astrophysical tau neutrinos at a 5σ significance level, aligning with existing IceCube measurements and theoretical predictions regarding neutrino flux and oscillations.
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  • * The study analyzed IgG N-glycans in over 1200 individuals, revealing that PLWH show more significant glycan changes associated with aging and inflammation compared to those without HIV.
  • * These glycan alterations are linked to higher inflammation markers and worse health outcomes, suggesting they could be used to develop new biomarkers to help monitor and prevent age-related diseases in PLWH.
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Introduction: Nocturia is a complex and multifactorial condition, associated with several genitourinary abnormalities as well as a host of conditions beyond the urinary tract, and thus often poses a significant diagnostic challenge in real-world practice. Sleep Disorders, Comorbidities, Actions, Lower Urinary Tract Dysfunction, and Medications, the so-called "Sleep C.A.

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Purpose: Nocturia significantly impacts patients' quality of life but remains insufficiently evaluated and treated. The "Sleep C.A.

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Introduction: Minimally invasive approaches to lung resection have become widely acceptable and more recently, segmentectomy has demonstrated equivalent oncologic outcomes when compared to lobectomy for early-stage non-small cell lung cancer (NSCLC). However, studies comparing outcomes following segmentectomy by different surgical approaches are lacking. Our objective was to investigate the outcomes of patients undergoing robotic, video-assisted thoracoscopic surgery (VATS), or open segmentectomy for NSCLC using the National Cancer Database.

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  • People with HIV (PWH) are at greater risk of cardiovascular disease due to conditions like myocardial fibrosis and inflammation, with previous studies focusing mostly on men and healthy volunteers for comparison.* -
  • This study investigated female participants with HIV and found that a significant percentage had undetectable viral loads but struggled with medication adherence, which is linked to increased myocardial inflammation and fibrosis.* -
  • The findings highlight the need for better ART adherence strategies and understanding of latent infections to reduce heart-related complications in women living with HIV.*
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  • The study investigates the link between HIV, hepatitis C virus (HCV), and the presence of carotid artery atherosclerotic plaques, which are related to an increased risk of stroke.
  • Conducted on participants from the MACS/WIHS Combined Cohort Study, researchers used high-resolution ultrasound to analyze plaque characteristics and controlled for various demographic and health factors in their analysis.
  • Findings show that individuals with HIV, especially those with a low CD4 count, and those with HCV—either alone or in combination with HIV—exhibited different types of plaques, indicating various risk profiles for cardiovascular issues.
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Background: Effective screening for oropharyngeal cancer is lacking. Four oncogenic HPV clearance definitions were explored to understand long-term natural history for persistent oncogenic oral HPV (oncHPV), the precursor of oropharyngeal cancer.

Methods: Prospective multicenter cohort of participants living with/at-risk for HIV, with oral rinse and gargle samples collected every 6 to 12 months for up to 10 years and tested for oncHPV.

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Problem: Transition to residency (TTR) courses help alleviate medical students' concerns about preparing for residency; however, existing TTR courses are often limited to teaching clinical or procedural skills without addressing the nonclinical skills necessary for transitioning to practice. This report describes the use of design thinking (DT) to develop a learner-centered TTR course at the State University of New York Downstate Health Sciences University.

Approach: DT consists of 5 steps: discovery, interpretation, ideation, experimentation, and evolution.

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Nocturia has been increasingly recognized as a manifestation of various non-urological conditions including hypertension. In adults, blood pressure (BP) elevation has been identified as a robust correlate of nocturia, but such a relationship has not been studied in pediatric populations where nocturia is often attributed to hormonal, sleep, physiological or psychological disorders. Accordingly, this study aimed to determine the relationship between nocturia and BP elevation in adolescents.

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Aims: The link between nocturia and cardiovascular disease (CVD) is frequently discussed in literature, yet the precise nature of this relationship remains poorly characterized. The existing literature was reviewed in order to address issues concerning the origin, diagnosis, management, and implications of the co-occurrence of CVD and nocturia.

Methods: This review summarizes literature and recommendations regarding the link between CVD and nocturia discussed during a think-tank meeting held at the 2023 International Consultation on Incontinence-Research Society.

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Tactile graphics are one of the best ways for a blind person to perceive a chart using touch, but their fabrication is often costly, time-consuming, and does not lend itself to dynamic exploration. Refreshable haptic displays tend to be expensive and thus unavailable to most blind individuals. We propose TACTUALPLOT, an approach to sensory substitution where touch interaction yields auditory (sonified) feedback.

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The human proteome is more complex than the genetic code predicts it to be. Epitomics, or protein epitome profiling, is a tool for understanding sub-protein level variation. With the ultimate goal to explore C9 proteoforms and their relevance to lung cancer, here we report plasma C9 epitope-associated molecular heterogeneity in plasma samples of lung cancer patients and control subjects.

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  • The study compares the subjective Global Evaluative Assessment of Robotic Skills with objective performance indicators derived from robotic-assisted surgery data to determine their correlation and effectiveness during a lobectomy procedure.
  • Data including video, system events, and instrument movements were recorded and analyzed from surgeries on a porcine model, with expert surgeons grading the procedures independently.
  • Results showed that while attending surgeons scored significantly higher, there was notable variability in scoring, and certain objective indicators, especially related to efficiency and instrument movement, correlated well with the subjective assessment scores.
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Background: Abiraterone (Abi) is an androgen receptor signaling inhibitor that significantly improves patients' life expectancy in metastatic prostate cancer (PCa). Despite its beneficial effects, many patients have baseline or acquired resistance against Abi. The aim of this study was to identify predictive serum biomarkers for Abi treatment.

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