NiCoP/g-CN Nanocomposites-Based Electrochemical Immunosensor for Sensitive Detection of Procalcitonin.

Herein, an ultra-sensitive and facile electrochemical biosensor for procalcitonin (PCT) detection was developed based on NiCoP/g-CN nanocomposites. Firstly, NiCoP/g-CN nanocomposites were synthesized using hydrothermal methods and then functionalized on the electrode surface by π-π stacking. Afterward, the monoclonal antibody that can specifically capture the PCT was successfully linked onto the surface of the nanocomposites with a 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-Hydroxysuccinimide (NHS) condensation reaction.

Construction of a non-enzymatic electrochemical sensor based on graphitic carbon nitride nanosheets for sensitive detection of procalcitonin.

In this study, we established a label free and ultrasensitive electrochemical sensor based on graphitic nitride nanosheets (g-CN NS) for procalcitonin (PCT) detection. Firstly, an easy-to-prepare and well-conducting g-CN NS was synthesized. Next the g-CN NS was immobilized on the electrode surface by π-π stacking, and further used to anchor the specific recognition peptide (PP).