The study investigates how electroacupuncture (EA) can improve intestinal motility in rats with slow transit constipation (STC) by affecting exosomal miR-34c-5p levels.
EA was shown to increase miR-34c-5p in serum exosomes while decreasing it in colonic tissues, ultimately enhancing fecal output and transit rates.
The positive effects of EA were linked to the activation of the SCF/c-Kit signaling pathway, but these effects diminished when exosome release was inhibited.