Publications by authors named "Layth Saymeh"
Article Synopsis
- TGFalpha promotes the release of the neuropeptide CGRP from gastric sensory neurons, enhancing mucosal protection and healing.
- Both CGRP and capsaicin inhibit the baseline release of TGFalpha, indicating a complex regulatory interaction.
- Capsaicin-induced sensory denervation increased TGFalpha levels, highlighting how sensory neurons and TGFalpha interact in gastric physiology.
Primary aortoenteric fistula (PAEF) is a well-known but rare cause of gastrointestinal bleeding. The diagnosis can be difficult since the majority of patients do not have classical symptoms. "Herald bleed" is usually followed by a massive hemorrhage.
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- TGF-alpha plays a protective role against stomach mucosal injury caused by ethanol, but the exact mechanisms are not fully understood.
- Researchers conducted experiments on fasted rats to assess the contributions of sensory neurons, neuropeptides (CGRP and substance P), and prostaglandins to this gastroprotective effect.
- The study found that TGF-alpha significantly reduced gastric lesions and relied on the activation of sensory neurons and release of CGRP, while neither substance P nor prostaglandins were necessary for this protection.
Exogenously administered TGF alpha has been shown to protect rodent gastric mucosa against injury caused by acid-dependent and acid-independent injury. The present study examined whether the gastroprotective effects of TGF alpha on stress-induced gastric ulceration in the rat involves activation of capsaicin-sensitive sensory neurons. Fasted male SD rats were subjected to water restraint stress (WRS) for four hours.
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