Standardized reporting of pulmonary transfusion complications: Development of a model reporting form and flowchart.

Background: Pulmonary complications of blood transfusion, including transfusion-related acute lung injury (TRALI), transfusion-associated circulatory overload (TACO), and transfusion-associated dyspnea, are generally underdiagnosed and under-reported. The international TRALI and TACO definitions have recently been updated. Currently, no standardized pulmonary transfusion reaction reporting form exists and most of the hemovigilance forms have not yet incorporated the updated definitions.

Longitudinal growth during fetal life and infancy and cardiovascular outcomes at school-age.

Objective: Low birth weight is associated with cardiovascular disease. We examined the effects of fetal and infant growth patterns on cardiovascular outcomes in children.

Methods: In a population-based prospective cohort study among 6239 children, we estimated fetal-femur length and weight by 20 and 30 weeks ultrasound, and child length and weight at birth, 0.

Fetal exposure to parental smoking and the risk of type 2 diabetes in adult women.

Objective: We evaluated the associations of both maternal and paternal smoking during pregnancy with the risk of type 2 diabetes in daughters and explored whether any association was explained by weight at birth or BMI throughout life.

Research Design And Methods: We used data from 34,453 participants of the Nurses' Health Study II. We used Cox proportional hazards models to examine the associations of maternal and paternal smoking during pregnancy with incidence of type 2 diabetes in daughters between 1989 and 2009.

Third trimester fetal hemodynamics and cardiovascular outcomes in childhood: the Generation R study.

Objective: Low birth weight is associated with cardiovascular disease in adulthood. Hemodynamic adaptations related to fetal growth restriction may underlie these associations, through persistent influences on cardiovascular development. We examined the associations of third trimester fetal hemodynamics with cardiovascular outcomes in childhood.

First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study.

Objective: To examine whether first trimester fetal growth restriction correlates with cardiovascular outcomes in childhood.

Design: Population based prospective cohort study.

Setting: City of Rotterdam, the Netherlands.

Parental smoking during pregnancy and cardiovascular structures and function in childhood: the Generation R Study.

Background: Foetal smoke exposure might lead to foetal developmental adaptations that permanently affect the cardiovascular system. We assessed the associations of both maternal and paternal smoking during pregnancy with childhood cardiovascular structures and function.

Method: In a prospective cohort study among 5565 children, we examined whether maternal and paternal smoking during pregnancy are associated with blood pressure, carotid-femoral pulse wave velocity and left cardiac structures and function in 6-year-old children.

Infant feeding patterns are associated with cardiovascular structures and function in childhood.

Nutrition in infancy seems to be associated with cardiovascular disease and its risk factors in adulthood. These associations may be explained by cardiovascular developmental adaptations in childhood in response to specific infant feeding patterns. The aim of this study was to assess whether duration and exclusivity of breastfeeding and timing of introduction of solid foods affect cardiovascular development in childhood.

Maternal educational level and blood pressure, aortic stiffness, cardiovascular structure and functioning in childhood: the generation R study.

Background: In adults, low level of education was shown to be associated with higher blood pressure levels and alterations in cardiac structures and function. It is currently unknown whether socioeconomic inequalities in arterial and cardiac alterations originate in childhood. Therefore, we investigated the association of maternal education with blood pressure levels, arterial stiffness, and cardiac structures and function at the age of 6 years and potential underlying factors.

Infant macronutrient composition is associated with differences in cardiovascular structures and function in childhood.

Early-life nutrition may influence cardiovascular development. Not much is known about the associations between dietary composition and cardiovascular risk factors in childhood. We examined the associations of infant macronutrient intake with cardiovascular structures and function in 2882 children participating in a prospective, population-based cohort study.

Maternal first-trimester dietary intake and childhood blood pressure: the Generation R Study.

Suboptimal maternal dietary intake during pregnancy might lead to fetal cardiovascular adaptations and higher blood pressure in the offspring. The aim of the present study was to investigate the associations of maternal first-trimester dietary intake with blood pressure in children at the age of 6 years. We assessed first-trimester maternal daily dietary intake by a FFQ and measured folate, homocysteine and vitamin B₁₂ concentrations in the blood, in a population-based prospective cohort study among 2863 mothers and children.

Parental psychological distress during pregnancy and childhood cardiovascular development. The Generation R Study.

Background: Maternal psychological distress during pregnancy might lead to higher fetal cortisol exposure, which subsequently leads to fetal cardiovascular developmental adaptations and cardiovascular dysfunction in later life.

Aims: We examined whether maternal and paternal psychological distress was associated with the cardiovascular outcome measurements in school age children.

Study Design And Subjects: In a population-based prospective cohort study among 4831 children, we assessed maternal and paternal psychological distress during pregnancy by questionnaire, using the Brief Symptom Inventory (see Fig.

Parental smoking in pregnancy and the risks of adult-onset hypertension.

Fetal exposure to parental smoking may lead to developmental adaptations and promote various diseases in later life. This study evaluated the associations of parental smoking during pregnancy with the risk of hypertension in the daughter in adulthood, and assessed whether these associations are explained by birth weight or body weight throughout life. We used data on 33086 participants of the Nurses' Health Study II and the Nurses' Mothers' Cohort.

C-reactive protein levels, blood pressure and the risks of gestational hypertensive complications: the Generation R Study.

Objectives: Aim of this study was to investigate the associations of C-reactive protein levels, as marker of low-grade inflammation, with blood pressure development during pregnancy and the risks of gestational hypertensive complications. We also explored the role of maternal BMI in these associations.

Methods: High-sensitivity C-reactive protein levels were measured in early pregnancy (median 13.

C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R Study.

Objective: We sought to examine the associations of maternal C-reactive protein (CRP) levels with fetal growth and the risks of neonatal complications.

Study Design: CRP levels were measured in early pregnancy in 6016 women. Main outcome measures were fetal growth in each trimester and neonatal complications.

Growth, obesity, and cardiac structures in early childhood: the Generation R Study.

Cardiac structural adaptations in response to physical growth and obesity in older children have been identified and might have long-term consequences. We examined the associations of growth and obesity with cardiac structures during the first 2 years of life. In a population-based prospective cohort study among 974 children, left atrial diameter, left ventricular diastolic diameter, left ventricular mass, aortic root diameter, and fractional shortening were repeatedly measured by ultrasound at the ages of 1.

Breastfeeding is not associated with left cardiac structures and blood pressure during the first two years of life. The Generation R Study.

Background: Shorter duration of breastfeeding in infancy has been suggested to be associated with an increased risk of cardiovascular disease in adulthood. Early cardiovascular adaptations due to breastfeeding may explain these associations.

Aim: To investigate whether breastfeeding affects left cardiac structures and blood pressure development in early childhood.

Indirect maternal mortality increases in the Netherlands.

Objective: To assess causes, trends, and substandard care in indirect maternal mortality in the Netherlands.

Design: Confidential enquiry into causes of maternal death.

Setting: Nationwide in the Netherlands.