Relationship between serum resistin, body fat and inflammatory markers in females with clinical knee osteoarthritis.

Objectives: Adipokines have gained much interest in osteoarthritis (OA) pathogenesis studies over the past years in that they play crucial roles in bone and cartilage homeostasis. Obesity is known to be one of the well-recognized and modifiable causes of OA burden. Key mediators in this metabolic link between obesity and OA could be resistin, among other cytokines secreted by the adipose tissue.

Association between serum resistin, adiposity measures and inflammatory makers in women without cardiovascular diseases.

Aims: The convergence of obesity and inflammation in the pathogenesis of cardiovascular diseases (CVD) has been recognized over the past decade. Resistin has emerged as a novel secreted protein with links to both insulin resistance and inflammation. We aimed to investigate the relationship between changes in serum resistin levels with metabolic parameters, including obesity and inflammatory markers in women free of CVD.