Suppression of Mediator Subunit-Encoding Confers Broad Resistance Against DNA and RNA Viruses While Is Required for Virus Defense.

Mediator subunits play key roles in numerous physiological pathways and developmental processes in plants. Mediator subunits, MED18 and MED25, have previously been shown to modulate disease resistance against fungal and bacterial pathogens through their role in jasmonic acid (JA) signaling. In this study, mutant plants of the two Mediator subunits, and , were tested against three ssRNA viruses and one dsDNA virus belonging to four different families: (TuMV), (CaMV), (AltMV), and (CMV).