Publications by authors named "Layla El Qadi"
Introduction: We aimed to report the demographic data, clinical features, and management outcomes of patients with uveal melanoma (UM) in a single tertiary center in Egypt.
Methods: This is a single-center retrospective case series. Patients with UM who were managed at Cairo University Ocular Oncology Service between January 2019 and December 2023 were included.
Article Synopsis
- * Conducted at Cairo University, it included a retrospective analysis of 7 male patients, with a significant mean age of 39.3 years, all of whom showed marked improvement in vision and tumor size after treatment.
- * Results indicated that the therapy not only reduced tumor dimensions and resolved associated complications, but also highlighted a positive safety profile, with no recurrences or significant radiation-related issues reported during a follow-up period of about 12.5 months.
COVID-19 has shown a substantial variation in the rate and severity by which it impacts different demographic groups. Specifically, it has shown a predilection towards obese patients as well as well as other vulnerable groups including predilection of males over females, old age over young age and black races over Caucasian ones. Single cell sequencing studies have highlighted the role of cell polarity and the co-expression of proteases, such as Furin, along with ACE2 in the genesis of coronavirus disease rather than exclusively link tissue involvement with ACE2 levels thought previously.
View Article and Find Full Text PDFFurin, a cleavage enzyme, is increasingly recognized in the pathogenesis of metabolic syndrome. Its cleavage action is an essential activation step for the endothelial pathogenicity of several viruses including SARS-CoV-2. This Furin-mediated endothelial tropism seems to underlie the multi-organ system involvement of COVID-19; which is a feature that was not recognized in the older versions of coronaviridae.
View Article and Find Full Text PDFArticle Synopsis
- COVID-19 is a serious global illness that puts pressure on hospital resources, particularly in ICU and ventilator availability, due to severe complications.
- The disease is primarily linked to microvascular damage caused by high levels of interleukin 6 (IL-6), which affects multiple organ systems, including respiratory and cardiac.
- Researchers recommend conducting studies to measure IL-6 levels in infected patients to predict severe outcomes, allowing for early treatment with IL-6 inhibitors to reduce ICU admissions and alleviate strain on healthcare systems.