Publications by authors named "Laxmikant Pandey"
Article Synopsis
- - The 3A region of the foot-and-mouth disease virus (FMDV) plays a crucial role in its host range and virulence, showing significant variability with a high percentage of amino acid substitutions, particularly in its flexible C-terminal region.
- - In India, a new variant of the A serotype virus exhibited an important deletion in the VP3 cap protein, and despite differences in the phylogenetic grouping of the 3A region compared to the 1D region, this variant still retains a distinct evolutionary path.
- - Twelve specific amino acid changes were identified in the 3A region, with some under positive selection, potentially enhancing the virus's ability to adapt to various hosts and spread rapidly; a specific
Genotype inclusive grouping of Indian type A isolates as observed in 1D region based phylogeny was distorted at complete L(pro) region, where the VP3(59)-deletion group lineages of genotype VII clustered away from both genotypes VII and VI, confirming its uniqueness and independent evolution of L(pro) and 1D region. Akin to the 1D region, this deletion group is gradually diverging genetically even at L region forming more number of lineages and inter-lineage distance at L region is considerably more than that for 1D region. The deletion group is restricted to India only as none of the exotic sequences clustered within this group.
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