Electrical properties of rat dorsal root ganglion neurones with different peripheral nerve conduction velocities.

The electrical characteristics of individual rat dorsal root ganglion neurones were studied and related to the peripheral axon conduction velocity and morphological cell type. Neurones were divided into four groups based on the conduction velocity of their peripheral axons (A alpha, 30-55 m/s; A beta, 14-30 m/s; A delta, 2.2-8 m/s and C less than 1.

Somatic and visceral primary afferents in the lower thoracic dorsal root ganglia of the cat.

Anterograde transport of horseradish peroxidase (HRP) through somatic and visceral nerves was used to estimate the proportions of somatic and visceral dorsal root ganglion (DRG) cells of the lower thoracic ganglia of the cat. A concentrated solution of HRP was applied for at least 5 hours to the central end of the right greater splanchnic nerve and of the left T9-intercostal nerve of adult cats. Some animals remained under chloralose anaesthesia for the duration of the HRP transport time (up to 53 hours) whereas longer HRP application and transport times (4-5 days) were allowed in animals that recovered from barbiturate anaesthesia.

A monoclonal antibody against neurofilament protein specifically labels a subpopulation of rat sensory neurones.

A monoclonal antibody (RT97) against neurofilament protein specifically and exclusively labelled a subpopulation of rat dorsal root ganglion (DRG) neurones. For seven ganglia (L4 and T13) studied quantitatively the frequency distribution histograms of the size of labelled cells could be fitted by a single normal distribution whose parameters were extremely close to those of the normally distributed large light cell population in that ganglion. On this basis and on the basis of a statistical analysis of the results it was suggested that this antibody can be used as a much needed specific label for the large light population of neurones in rat DRGs.

Incidence of squamous cell carcinoma in hairless mice irradiated with ultraviolet light in relation to intake of ascorbic acid (vitamin C) and of D, L-alpha-tocopheryl acetate (vitamin E).

We have carried out a study of large malignant skin tumours (squamous-cell carcinomas) and other lesions in "hairless" mice (in groups of 45 or 60 mice) intermittently exposed to ultraviolet light over a period of 15 weeks, beginning when the mice were about 8 weeks old. Various groups were given a standard diet (Wayne Lab-Blox) or the same food with added vitamin C or vitamin E throughout the study. Lesions, classified by histopathologic study as atypical squamous-cell proliferations varying from early actinic keratoses to invasive poorly differentiated squamous-cell carcinomas, had begun to develop by the end of the period of irradiation.

The effect of laparoscopic sterilisation by diathermy or silastic bands on post-operative pain, menstrual symptoms and sexuality.

A total of 530 patients was reviewed six months after laparoscopic sterilisation by diathermy (235 patients) or silastic bands (295 patients). In the immediate postoperative period severe lower abdominal pain was more common in the patients who had silastic bands. There was no differences in the nature or incidence of menstrual problems when the two methods were compared.

The postnatal development of large light and small dark neurons in mouse dorsal root ganglia: a statistical analysis of cell numbers and size.

A method is described for the analysis of cell types in mouse dorsal root ganglia using the distribution of cell cross-sectional areas measured at the level of the nucleolus in 1.5 micron Epon sections. Using a computer program it was possible to demonstrate the existence of two normally distributed sub-populations of neurons in all the 3rd lumbar segment ganglia (17 in number) measured at various ages from birth to 70 days.

Development of mouse dorsal root ganglia: an autoradiographic and quantitative study.

Pulse labelling with tritiated thymidine was used to determine the cell birthdays of dorsal root ganglion (DRG) neurons in foetal mice. The peak number of cell birthdays occurred at 11.5 days foetal age in cervical DRGs, and at 12.

An ergonomic appraisal of the use and functional efficiency of condom urinals in the male patient with spinal cord paralysis.

The variety and method of use of condom urinals was reviewed and an investigation conducted to ascertain the problems which arise. Effects arising from material failure and methods of use were disclosed.

Second primary cancer after irradiation of laryngeal cancer.

Thirty (5.6%) of 535 patients followed 5-25 years after treatment of cordal carcinoma (T1A,B) developed a second primary laryngeal carcinoma. When analyzed by treatment modality, 3.