Sera from patients with Crohn's disease were tested for antibodies against organisms which are thought to cause inflammatory bowel disease in animals, or have been implicated in human Crohn's disease. Control sera were collected from healthy individuals and patients with ulcerative colitis. Sera from Crohn's disease and controls failed to agglutinate Clostridium colinum or Campylobacter sputorum subsp.
View Article and Find Full Text PDFThe weaned pig proved resistant to infection with Campylobacter sputorum subsp mucosalis after oral dosing. Pretreatment with benzetimide to reduce gastrointestinal peristalsis allowed mucosalis infection to be established.
View Article and Find Full Text PDFPigs dosed orally with Campylobacter sputorum subsp mucosalis in the neonatal period became infected and mucosalis was recovered from the intestinal mucosa for up to 40 days after infection. Rapid spread to undosed litter mates occurred. Gross adenomatous change did not develop.
View Article and Find Full Text PDF80 mg sodium cromoglycate (SCG) was administered by inhalation to two COPD-affected animals known to have respiratory hypersensitivity to Micropolyspora faeni. SCG treatment 20-30 minutes prior to inhalation challenge with M. faeni prevented exacerbation of respiratory disease, usually seen 4-8 hours after challenge.
View Article and Find Full Text PDFBreed, age, weight, type of work performed, seasonal onset, poor ventilation and exposure to moulds in the habitat were investigated in relation to the occurrence of chronic obstructive pulmonary disease (COPD). COPD was most commonly detected in showjumping and hacking horses. The older a horse, the more likely it was to become affected although most were 6 to 10 years of age.
View Article and Find Full Text PDFMicropolyspora faeni and Aspergillus fumigatus were identified as common causes of respiratory hypersensitivity in horses affected with chronic obstructive pulmonary disease (COPD). Rye grass pollen and an Actinomycete evoked respiratory allergy in a few horses. Not infrequently, individual horses were found to have respiratory hypersensitivity to two or more antigens.
View Article and Find Full Text PDFThis study indicates that viable Campylobacter sputorum subsp mucosalis are not present or are present in small numbers in the mucosa of pigs dying of proliferative haemorrhagic enteropathy. The changes present in the mucosa are similar to those seen in pigs recovering from adenomatosis and the evidence obtained indicates that the intracellular organisms observed in this condition are indeed mucosalis. The presence of large amounts of IgA in the altered tissue of both proliferative haemorrhagic enteropathy and porcine intestinal adenomatosis indicates that the failure to recover bacteria may be immunologically mediated but is not simply related to the presence or absence of antibody in the respective conditions.
View Article and Find Full Text PDFThe sera of horses affected and not affected with chronic obstructive pulmonary disease (COPD) were examined for precipitins to Micropolyspora faeni and Aspergillus fumigatus. Precipitins to both antigens were not restricted to COPD cases but occurred more frequently in animals affected with COPD. Many animals without detectable precipitins responded clinically to inhalation challenge with these antigens.
View Article and Find Full Text PDFThe weight gains of pigs in a hysterectomy-derived herd were evaluated using the cumulative sum technique. Representative animals growing poorly were selected by this method and a high proportion were found to be affected with porcine intestinal adenomatosis. Some possible effects of the condition on production in the herd were evaluated from these findings.
View Article and Find Full Text PDFThe preferred listening rate of speech was investigated in 30 men and 30 women aged 18--87 yrs. Ss were presented auditorially a reading of a standard prose passage and themselves adjusted a Varispeech I time compressor/expander to yield preferred listening rate. Differences in rate preference were significant for age but not for sex differences.
View Article and Find Full Text PDFHistochemical studies of normal and adenomatous intestinal mucosa of the pig showed the adenomatous epithelium to be deficient in enzymes normally found in mature absorptive cells. Electron microscopic studies confirmed that the adenomatous cells closely remsembled the crypt cells of normal mucosa.
View Article and Find Full Text PDFCampylobacter sputorum subsp mucosalis is the vibrio associated with a group of porcine enteropathies in which it is believed the primary lesion is that of adenomatosis. The surface antigens of mucosalis were investigated and individual factor sera were produced; these were used to examine a range of field strains from adenomatosis, necrotic enteritis, regional ileitis and proliferative haemorrhagic enteropathy. Neither these not sequential isolants from the same farm showed any distinctive antigenic pattern and it is suggested that changes in the surface antigens take place during the intracellular existence of the organism.
View Article and Find Full Text PDFA variant of Campylobacter sputorum subspecies mucosalis which is serologically distinct from all strains previously examined is described. It has been isolated from cases of porcine intestinal adenomatosis and necrotic enteritis and in all other characteristics conforms to the description of mucosalis.
View Article and Find Full Text PDFCatalase-negative vibrios can be isolated in large numbers from the affected intestinal mucosa of pigs suffering from a range of porcine enteropathies in which the mucosa has an adenomatous component. These vibrios cannot be distinguished from strains of Campylobacter sputorum subsp. mucosalis.
View Article and Find Full Text PDFBull Soc Med Afr Noire Lang Fr
April 1977
During the winter of 1971-72 faecal samples from 91 diarrhoeic calves, 25 of which were considered to be suffering from the "collapse syndrome" were examined bacteriologically. E coli of serotypes reported as having the ability to produce enterotoxins were isolated from most of the calves with the "collapse syndrome", but from only a few of the other diarrhoeic calves, as well as a few unaffected in-contact animals. On post mortem examination, abomasal dilatation was a characteristic finding in calves dying of the "collapse syndrome" but not of other diarrhoeic deaths.
View Article and Find Full Text PDFAn outbreak of a haemorrhagic enteropathy in a closed herd of pigs was followed by the appearance, in the same herd, of cases of intestinal adenomatosis. This paper now draws attention to similarties in the mucosal pathology which are present in the two conditions. The affected tissue showed substantial epithelial proliferation and retrospective electron microscopic studies of material from both these entities revealed the presence of bacteria of similar morphology within the cytoplasm of these epithelial cells.
View Article and Find Full Text PDF© LitMetric 2025. All rights reserved.